Table 3 Duration of severe neutropenia in cycles 1, 2, 3, and 4 (ITT population)

1

N

125

250

Mean ± SD

2.3 ± 2.5

0.6 ± 1.1

Median (range)

2.0 (0–11.0)

0 (0–5.0)

LSM*

−1.661

95% CI*

−2.089 to −1.232

P value*

<0.0001

2

N

122

244

Mean ± SD

2.2 ± 2.6

0.3 ± 0.7

Median (range)

1.0 (0–11.0)

0 (0–4.0)

LSM*

−1.915

95% CI*

−2.317 to −1.512

P value*

<0.0001

3

N

122

245

Mean ± SD

2.0 ± 2.4

0.4 ± 0.9

Median (range)

1.0 (0–11.0)

0 (0–5.0)

LSM*

−1.640

95% CI*

−2.053 to −1.227

P value*

<0.0001

4

N

123

246

Mean ± SD

2.3 ± 2.5

0.5 ± 1.1

Median (range)

1.0 (0–11.0)

0 (0–0.8)

LSM*

−1.844

95% CI*

−2.281 to −1.407

P value*

<0.0001