Antidiabetic, antioxidant, antihyperlipidemic effect of extract of Euryale ferox salisb. with enhanced histopathology of pancreas, liver and kidney in streptozotocin induced diabetic rats

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Table 7 Effect of Euryale ferox salisb. seeds extract (EFx) on oxidative stress parameters in liver of normal and STZ induced diabetic treated rats

Groups	Oxidative stress
Groups	SOD (units/mg protein)	CAT (µ mol/min/mg protein)	GSH-px ((µ mol/min/mg protein)	GSH (mM/100 g tissue)
Normal rats [untreated with dimethylsulfoxide, (DMSO)] Group 1	12.30 ± 0.1642^a	82.84 ± 0.6566^a	13.71 ± 0.1077^a	53.63 ± 0.1813^a
Diabetic control [administered with Streptozotocin (STZ)] Group 2	3.670 ± 0.07218^b	22.28 ± 0.2578^b	5.274 ± 0.1402^b	21.98 ± 0.2745^b
Diabetic + (EFx) (100 mg/kg body weight) group 3	5.726 ± 0.1197	36.09 ± 0.2578	7.628 ± 0.08243	35.30 ± 0.3952
Diabetic + (EFx) (200 mg/kg body weight) Group 4	8.366 ± 0.01965	48.08 ± 0.4018	8.820 ± 0.01304	39.09 ± 0.2614
Diabetic + (EFx) (300 mg/kg body weight) Group 5	9.440 ± 0.1626	68.61 ± 0.2086	10.29 ± 0.2236	43.76 ± 0.4200
Diabetic + (EFx) (400 mg/kg body weight) Group 6	11.47 ± 0.1209^***	76.68 ± 0.8596^**	12.64 ± 0.04104^***	50.91 ± 0.3273^***
Diabetic + Glibenclamide (1 mg/kg body weight) Group 7	9.608 ± 0.1329^**	71.70 ± 0.3430^**	10.53 ± 0.1955^**	34.52 ± 0.3057^**

The data are expressed as mean ± SEM (n = number of animals in each group = 5). The comparisons has been made by one way ANOVA followed by Dunnent’s test.
ns non-significant, STZ Streptozotocin.
* p < 0.05 is considered as significant when compared to the control group (0 h).
** p < 0.001 is considered as very significant when compared to the control group (0 h).
*** p < 0.001 is considered as extremely significant when compared to the control group (0 h).
^aCompared to diabetic control.
^bCompared to normal control.