Antidiabetic, antioxidant, antihyperlipidemic effect of extract of Euryale ferox salisb. with enhanced histopathology of pancreas, liver and kidney in streptozotocin induced diabetic rats

SpringerPlus

Table 4 Effect of Euryale ferox salisb. seeds extract (EFx) on body weight variation (grams) in normal and STZ induced diabetic treated rats

Groups	Time (h)
Groups	1st day	45th day
Normal rats [untreated with dimethylsulfoxide, (DMSO)] Group 1	263.6 ± 0.8124^a	265.0 ± 1.673^a
Diabetic control [(administered with Streptozotocin (STZ)] Group 2	213.8 ± 1.594^b	210.8 ± 0.4899^b
Diabetic + (EFx) (100 mg/kg body weight) Group 3	217.0 ± 1.140	222.8 ± 1.655
Diabetic + (EFx) (200 mg/kg body weight) Group 4	220.6 ± 0.2449	234.2 ± 1.463
Diabetic + (EFx) (300 mg/kg body weight) Group 5	222.6 ± 0.5099	237.6 ± 0.5099
Diabetic + (EFx) (400 mg/kg body weight) Group 6	226.2 ± 0.8000	252.6 ± 1.631^**
Diabetic + glibenclamide (1 mg/kg body weight) Group 7	227.0 ± 0.9487	262.0 ± 0.7071^***

The data are expressed as mean ± SEM (n = number of animals in each group = 5). The comparisons has been made by one way ANOVA followed by Dunnent’s test.
ns non-significant, STZ Streptozotocin.
* p < 0.05 is considered as significant when compared to the control group (0 h).
** p < 0.001 is considered as very significant when compared to the control group (0 h).
*** p < 0.001 is considered as extremely significant when compared to the control group (0 h).
^a Compared to diabetic control.
^bCompared to normal control.