Antidiabetic, antioxidant, antihyperlipidemic effect of extract of Euryale ferox salisb. with enhanced histopathology of pancreas, liver and kidney in streptozotocin induced diabetic rats

SpringerPlus

Table 1 Effect of Euryale ferox salisb. seeds extract (EFx) on blood glucose level in normal and STZ induced diabetic treated rats

Groups	Blood glucose level in mg/dL at different time intervals during experimentation
Groups	At start (on 1st day)	On 21st day	On 45th day
Normal rats [untreated with dimethylsulfoxide, (DMSO)] Group 1	82.38 ± 0.6308^a	82.25 ± 0.2649^a	81.80 ± 0.4055^a
Diabetic control [administered with streptozotocin (STZ)] Group 2	303.8 ± 0.9011^b	310.5 ± 0.2231^b	312.5 ± 0.4212^b
Diabetic + (EFx) (100 mg/kg body weight) Group 3	301.0 ± 0.2698	264.1 ± 1.152	201.7 ± 0.3738
Diabetic + (EFx) (200 mg/kg body weight) Group 4	297.8 ± 0.3096	235.4 ± 0.8799	173.1 ± 0.8970
Diabetic + (EFx) (300 mg/kg body weight) Group 5	295.4 ± 0.3857	184.0 ± 0.6072	107.6 ± 1.422^**
Diabetic + (EFx) (400 mg/kg body weight) Group 6	293.6 ± 0.3771	146.7 ± 0.5004	91.08 ± 0.5402^***
Diabetic + glibenclamide (1 mg/kg body weight) Group 7	290.9 ± 0.2182	117.4 ± 1.004^**	83.14 ± 0.6532^***

The data are expressed as mean ± SEM (n = number of animals in each group = 5). The comparisons has been made by one way ANOVA followed by Dunnent’s test.
ns non-significant, STZ Streptozotocin.
* p < 0.05 is considered as significant when compared to the control group (0 h).
** p < 0.001 is considered as very significant when compared to the control group (0 h).
*** p < 0.001 is considered as extremely significant when compared to the control group (0 h).
^aCompared to diabetic control.
^bCompared to normal control.