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Table 6 ERCC1 is significantly associated with pCR in ER- tumors (N = 41)

From: ERCC1 and CYP1B1 polymorphisms as predictors of response to neoadjuvant chemotherapy in estrogen positive breast tumors

Gene SNP Genotype N pCR (N = 15) OR 95% CI P value
rs # wt n %a
BRCA1 rs799917 C CC 17 5 29.4    
  Pro871leu   CT-TT 23 10 43.5    0.36
    NA 1 0     
SLCO1B3 rs11045585 A AA 28 9 32.1    
  IVS12-5676   AG-GG 13 6 46.2    0.39
CYP1B1 rs1056836 C CG 18 5 27.8    
Leu432Val   CC-GG 23 10 43.5    0.29
ERCC1 rs11615 T TT 17 3 17.6 1   
Asn118Asn   CT-CC 24 12 50.0 4.7 (1.06–20) 0.030
  1. Significant results are shown in italic.
  2. NA not applicable, pCR pathological complete response.
  3. aPercentages of evaluable patients.