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Table 6 ERCC1 is significantly associated with pCR in ER- tumors (N = 41)

From: ERCC1 and CYP1B1 polymorphisms as predictors of response to neoadjuvant chemotherapy in estrogen positive breast tumors

Gene

SNP

Genotype

N

pCR (N = 15)

OR

95% CI

P value

rs #

wt

n

%a

BRCA1

rs799917

C

CC

17

5

29.4

   
 

Pro871leu

 

CT-TT

23

10

43.5

  

0.36

   

NA

1

0

    

SLCO1B3

rs11045585

A

AA

28

9

32.1

   
 

IVS12-5676

 

AG-GG

13

6

46.2

  

0.39

CYP1B1

rs1056836

C

CG

18

5

27.8

   

Leu432Val

 

CC-GG

23

10

43.5

  

0.29

ERCC1

rs11615

T

TT

17

3

17.6

1

  

Asn118Asn

 

CT-CC

24

12

50.0

4.7

(1.06–20)

0.030

  1. Significant results are shown in italic.
  2. NA not applicable, pCR pathological complete response.
  3. aPercentages of evaluable patients.
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