SpringerPlus

Table 5 BRCA1, SLCO1B3 and CYP1B1 are significantly associated with pCR in ER + tumors (N = 71)

From: ERCC1 and CYP1B1 polymorphisms as predictors of response to neoadjuvant chemotherapy in estrogen positive breast tumors

Gene	SNP		Genotype	N	pCR (N = 10)		OR	95% CI	P value
Gene	rs #	wt	Genotype	N	n	%^a	OR	95% CI	P value
BRCA1	rs799917	C	CC	26	0	0.0
	Pro871Leu		CT-TT	42	9	21.4			0.010
			NA	3	1
SLCO1B3	rs11045585	A	AA	49	4	8.2	1
	IVS12-5676		AG-GG	21	6	28.6	4.50	(1.12–18.1)	0.032
			NA	1	0
CYP1B1	rs1056836	C	CG	26	0	0.0
CYP1B1	Leu432Val		CC-GG	45	10	22.2			0.011
ERCC1	rs11615	T	TT	22	1	1.5
	Asn118Asn		CT-CC	48	9	18.8			0.08
			NA	1	0

Significant results are shown in italic.
NA not applicable, pCR pathological complete response.
^aPercentages of evaluable patients.

Back to article page