Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 5 BRCA1, SLCO1B3 and CYP1B1 are significantly associated with pCR in ER + tumors (N = 71)

From: ERCC1 and CYP1B1 polymorphisms as predictors of response to neoadjuvant chemotherapy in estrogen positive breast tumors

Gene SNP Genotype N pCR (N = 10) OR 95% CI P value
rs # wt n %a
BRCA1 rs799917 C CC 26 0 0.0    
Pro871Leu   CT-TT 42 9 21.4    0.010
   NA 3 1     
SLCO1B3 rs11045585 A AA 49 4 8.2 1   
IVS12-5676   AG-GG 21 6 28.6 4.50 (1.12–18.1) 0.032
   NA 1 0     
CYP1B1 rs1056836 C CG 26 0 0.0    
Leu432Val   CC-GG 45 10 22.2    0.011
ERCC1 rs11615 T TT 22 1 1.5    
Asn118Asn   CT-CC 48 9 18.8    0.08
   NA 1 0     
  1. Significant results are shown in italic.
  2. NA not applicable, pCR pathological complete response.
  3. aPercentages of evaluable patients.