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Table 3 pCR is related to 4 SNPs (N = 114)

From: ERCC1 and CYP1B1 polymorphisms as predictors of response to neoadjuvant chemotherapy in estrogen positive breast tumors

Gene

SNP

Genotype

N

pCR (N = 25)

OR

95% CI

P value

rs #

wt

n

%a

BRCA1

rs799917

C

CC

44

5

11.4

1

  

Pro871leu

 

CT-TT

66

19

28.8

3.15

(1.08–9.2)

0.025

  

NA

4

1

    

SLCO1B3

rs11045585

A

AA

79

13

16.5

1

  

IVS12-5676

 

AG-GG

34

12

35.3

2.77

(1.10–6.7)

0.031

  

NA

1

0

    

CYP1B1

rs1056836

C

CG

45

5

11.1

1

 

0.020

Leu432Val

 

CC-GG

69

20

29.0

3.26

(1.12–9.5)

 

ERCC1

rs11615

T

TT

40

4

10.0

1

  

Asn118Asn

 

CT-CC

73

21

28.8

3.63

(1.15–11.5)

0.016

  

NA

1

0

    
  1. NA not applicable, pCR pathological complete response.
  2. aPercentages of evaluable patients.
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