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Table 4 Heritability of MetS

From: Dissecting metabolic syndrome components: data from an epidemiologic survey in a genetic isolate

Trait

Heritability (%)

p value*

Covariatesa (%)

MetSb

48

1.62 × 10−25

24

BP + HDL + TRIG

53

5.80 × 10−9

21

BP + HDL + WAIST

52

2.00 × 10−7

10

BP + HDL + TRIG + WAIST

34

0.003

19

BP + GLU + WAIST

17

0.09

14

BP + HDL + WAIST + TRIG + GLU

58

0.001

28

SBP (mmHg)

29

2.04 × 10−53

27

DBP (mmHg)

20

2.35 × 10−31

9

HDL (mg/dL)

60

7.72 × 10−221

10

TRIGc (mg/dL)

35

4.28 × 10−72

6

WAIST (cm)

41

1.74 × 10−70

29

GLUd (mg/dL)

31

2.72 × 10−58

38

  1. The 9,647 individuals in this study sample were included into 589 pedigrees counting 16,463 members (mean size, 27.9 subjects).
  2. BP blood pressure, DBP diastolic blood pressure, GLU fasting plasma glucose, HDL high density lipoprotein cholesterol, SBP systolic blood pressure, TRIG triglycerides, WAIST waist circumference.
  3. aFor quantitative traits it represents the percentage of variance explained by covariates, for dichotomous trait it represents Kullback–Leibler R-squared.
  4. bMetS as a dichotomous trait, according to the NCEP-ATPIII definition.
  5. cLogarithmic transformation has been applied.
  6. d reciprocal transformation has been applied.
  7. * Two sided p value for testing the null hypothesis that heritability = 0.
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