Table 1 Clinicopathologic and outcome features of superficial high-grade and deep low-grade tumors
Superficial high-grade | Deep low-grade | P value | |
|---|---|---|---|
No. cases (%) | 12 (29%) | 29 (71%) | |
Clinical features | |||
Patients’s age in years, median (IQR) | 52.5 (12.5) | 56 (19) | 0.11 |
Tumor size in cm, median (IQR) | 4.5 (4.125) | 5 (2.125) | 0.95 |
Anatomical location (%) | 0.89 | ||
Glans alone | 7/26 (27%) | 19/26 (73%) | |
Glans + coronal sulcus | 2/6 (33%) | 4/6 (67%) | |
Glans + coronal sulcus + forsekin | 3/9 (33%) | 6/9 (67%) | |
Pathologic features | |||
Histologic subtype (%) | 0.057 | ||
Usual SCC | 11/24 (46%) | 13/24 (54%) | |
Verrucous carcinoma | 0/7 (0%) | 7/7 (100%) | |
Papillary carcinoma | 0/3 (0%) | 3/3 (100%) | |
Warty carcinoma | 1/3 (33%) | 2/3 (67%) | |
Mixed carcinoma | 0/4 (0%) | 4/4 (100%) | |
Urethral invasion (%) | 0.7 | ||
Positive | 3/15 (20%) | 12/15 (80%) | |
Negative | 6/19 (32%) | 13/19 (68%) | |
Perineural invasion (%) | 1 | ||
Positive | 2/6 (33%) | 4/6 (67%) | |
Negative | 10/34 (29%) | 24/34 (71%) | |
Vascular invasion (%) | 0.57 | ||
Positive | 2/4 (50%) | 2/4 (50%) | |
Negative | 10/36 (28%) | 26/36 (72%) | |
Outcome features | |||
Inguinal lymph node metastasis (%) | 0.02 | ||
Positive | 4/5 (80%) | 1/5 (20%) | |
Negative | 8/36 (22%) | 28/36 (78%) | |
Tumor relapse (%) | 0.52 | ||
Local, regional or systemic relapse | 1/2 (50%) | 1/2 (50%) | |
No tumor relapse | 11/38 (29%) | 27/38 (71%) | |
Final nodal status (%) | 0.2 | ||
Positive | 4/8 (50%) | 4/8 (50%) | |
Negative | 8/33 (24%) | 25/33 (76%) | |
Death by disseminated cancer (%) | 1 | ||
Positive | 0/1 (0%) | 1/1 (100%) | |
Negative | 12/40 (30%) | 28/40 (70%) | |