Thermal allodynia measured in CCI mice and sham mice with cold plate test in number of lifts ±SE preoperatively and postoperatively in both ipsilateral (left) and contralateral (right) hind paw. Statistics were done with linear mixed models in which: *p<0.05 as compared with preoperative measurement, **p<0.01 as compared with preoperative measurement, ***p<0.001 as compared with preoperative measurement. A significant increase was seen from preoperatively to day 7 in both silk and catgut ligatured mice considering the left hind paw. In CCI mice with silk ligatures also a significant increase was seen from day 18 to day 21. In the CCI mice considering the right hind paw and the sham-mice the number of lifts remained constant.