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Table 2 Candidate causal pathways

From: Genetic variants and risk of gastric cancer: a pathway analysis of a genome-wide association study

Index Candidate causal pathway Description Nominal P FDR
1 Ephrin receptor binding Interacting selectively and non-covalently with an ephrin receptor <0.001 0.004
2 Hsa00983 Drug metabolism – other enzymes <0.001 0.032
3 Hsa00240 Pyrimidine metabolism 0.004 0.032
4 Hsa00460 Cyanoamino acid metabolism 0.007 0.033
5 Growth The increase in size or mass of an entire organism, a part of an organism or a cell 0.006 0.036
6 Kidney development The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure 0.003 0.038
7 Cellular cation homeostasis The regulation of the levels, transport, and metabolism of cations within a cell or between a cell and its external environment 0.009 0.039
8 Urogenital system development The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure <0.001 0.040
9 Lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids 0.006 0.040
10 Regulation of cell growth Any process that modulates the frequency, rate or extent of cell growth 0.002 0.042
11 Hsa00500 Starch and sucrose metabolism 0.003 0.043
12 Cation homeostasis The regulation of the levels, transport, and metabolism of cations 0.009 0.044
  1. FDR; false discovery rate.