Skip to main content

Table 1 Fold changes of stimulated miRNAs in healthy and atherosclerotic SMCs

From: Interleukin-6 and microRNA profiles induced by oral bacteria in human atheroma derived and healthy smooth muscle cells

  

HSMCs

AthSMCs

 
   

Percentiles

 

Percentiles

 

miRNA ID

Accession number

Median

25th

75th

Median

25th

75th

p-value*

hsa-miR-142-5p

MIMAT0000433

−1.58

−1.98

0.67

−0.05

−1.89

2.08

 

hsa-miR-9-5p

MIMAT0000441

−2.31

−4.05

−1.49

−1.51

−2.33

1.71

0.045

hsa-miR-150-5p

MIMAT0000451

−2.01

−2.69

−1.03

3.18

−0.4

4.31

0.002

hsa-miR-27b-3p

MIMAT0000419

−1.25

−1.53

1.05

−1.42

−1.74

0.68

 

hsa-miR-101-3p

MIMAT0000099

3.39

1.61

5.33

1.05

−1.47

2.05

0.007

hsa-let-7d-5p

MIMAT0000065

−1.26

−1.47

−1.05

1.05

−1.07

1.1

0.014

hsa-miR-103a-3p

MIMAT0000101

−0.02

−1.32

1.44

−1.07

−1.28

1.1

 

hsa-miR-16-5p

MIMAT0000069

−1.32

−1.76

0.48

−0.02

−1.17

1.19

 

hsa-miR-26a-5p

MIMAT0000082

−1.18

−1.4

1.2

−1.78

−2.04

−1.15

 

hsa-miR-32-5p

MIMAT0000090

1.22

−1.12

3.4

4.01

1.56

5.69

 

hsa-miR-26b-5p

MIMAT0000083

−1.37

−1.87

−1.08

−1.77

−2.19

−1.32

 

hsa-let-7 g-5p

MIMAT0000414

−1.41

−1.88

−1.18

−1.23

−1.56

0.53

 

hsa-miR-30c-5p

MIMAT0000244

−1.19

−1.52

1.09

−1.71

−2.25

−1.11

 

hsa-miR-96-5p

MIMAT0000095

−3.54

−4.93

−1.53

1.43

1.13

3.41

<0.001

hsa-miR-185-5p

MIMAT0000455

2.07

1.43

3.15

−1.25

−1.3

−1.02

<0.001

hsa-miR-142-3p

MIMAT0000434

−1.11

−1.54

2.65

2.18

1.9

3.98

0.014

hsa-miR-24-3p

MIMAT0000080

1.03

−1.13

1.25

−1.12

−1.48

1.22

 

hsa-miR-155-5p

MIMAT0000646

−1.4

−1.63

−1.18

1.06

−1.12

1.31

0.003**

hsa-miR-146a-5p

MIMAT0000449

−1.61

−2.01

−1.17

−2.01

−2.48

−1.32

 

hsa-miR-425-5p

MIMAT0003393

1.24

−0.5

1.49

−1.16

−1.65

0.61

 

hsa-miR-181b-5p

MIMAT0000257

−1.27

−1.39

−1.14

1.13

−0.55

1.34

<0.001**

hsa-miR-302b-3p

MIMAT0000715

−1.97

−3.13

0.46

−1.84

−2.83

−1.15

 

hsa-miR-30b-5p

MIMAT0000420

−1.09

−1.3

1.13

−1.25

−1.54

0.6

 

hsa-miR-21-5p

MIMAT0000076

−1.69

−2.72

−1.37

−1.98

−2.36

−1.23

 

hsa-miR-30e-5p

MIMAT0000692

1.46

1.09

2.09

−1.15

−1.45

1.18

0.008

hsa-miR-200c-3p

MIMAT0000617

−1.79

−2.51

−1.5

1.47

1.04

2.38

<0.001

hsa-miR-15b-5p

MIMAT0000417

−1.06

−1.29

1.12

−0.09

−1.47

1.24

 

hsa-miR-223-3p

MIMAT0000280

−2.6

−5.45

−1.14

−1.48

−1.8

7.44

 

hsa-miR-194-5p

MIMAT0000460

1.06

−1.24

1.47

−1.65

−2.01

0.59

 

hsa-miR-210-3p

MIMAT0000267

2.65

1.39

4.49

2.02

1.52

2.34

 

hsa-miR-15a-5p

MIMAT0000068

2.07

1.61

2.95

1.14

−1.4

1.8

0.024

hsa-miR-181a-5p

MIMAT0000068

1.78

1.33

2.72

1.34

−1.29

1.58

0.028

hsa-miR-125b-5p

MIMAT0000423

1.1

−1.11

1.5

−1.51

−2.11

−1.16

0.01

hsa-miR-99a-5p

MIMAT0000097

1.07

−1.12

1.41

−1.74

−2.04

0.55

 

hsa-miR-28-5p

MIMAT0000085

1.82

1.3

2.13

−1.43

−1.78

1.05

<0.001**

hsa-miR-320a

MIMAT0000510

−0.02

−1.46

1.22

1.13

−1.05

1.38

 

hsa-miR-125a-5p

MIMAT0000443

−1.48

−3.1

0.55

−1.21

−1.89

1.42

 

hsa-miR-29b-3p

MIMAT0000100

2.02

1.39

4.66

2

−1.1

2.65

 

hsa-miR-29a-3p

MIMAT0000086

1.43

−0.57

1.86

−1.03

−1.18

1.57

 

hsa-miR-141-3p

MIMAT0000432

−0.09

−1.98

2.1

2.08

−0.49

3.03

 

hsa-miR-19a-3p

MIMAT0000073

1.82

−0.51

3.2

−1.06

−1.37

1.69

 

hsa-miR-18a-5p

MIMAT0000072

0.05

−1.19

1.6

−0.04

−1.28

1.13

 

hsa-miR-374a-5p

MIMAT0000727

−1.28

−1.56

0.5

−1.53

−2.1

−1.03

 

hsa-miR-423-5p

MIMAT0004748

−1.2

−1.34

0.5

1.2

1.02

1.52

0.002

hsa-let-7a-5p

MIMAT0000062

−1.53

−1.9

−1.26

−1.02

−1.13

1.13

0.001

hsa-miR-124-3p

MIMAT0000422

1.15

−1.86

3.06

1.93

1.13

3.97

 

hsa-miR-92a-3p

MIMAT0000092

−0.03

−1.37

1.22

−1.06

−1.13

1.18

 

hsa-miR-23a-3p

MIMAT0000078

−1.34

−1.98

−1.04

−1.5

−1.7

−1.13

 

hsa-miR-25-3p

MIMAT0000081

−1.47

−2.14

−1.27

−1.73

−1.97

−1.08

 

hsa-let-7e-5p

MIMAT0000066

−1.55

−1.87

−1.26

1.16

−1.04

1.32

<0.001

hsa-miR-376c-3p

MIMAT0000720

2.08

1.34

2.73

−1.43

−1.63

1.5

0.006

hsa-miR-126-3p

MIMAT0000445

1.2

−1.08

1.98

−0.09

−1.52

1.44

 

hsa-miR-144-3p

MIMAT0000436

−2.07

−3.78

1.88

1.21

−1.49

3.64

 

hsa-miR-424-5p

MIMAT0001341

−1.46

−2.18

−1.09

−1.63

−1.78

0.44

 

hsa-miR-30a-5p

MIMAT0000087

1.6

1.1

2.06

−0.03

−1.24

1.35

 

hsa-miR-23b-3p

MIMAT0000418

−1.5

−1.99

0.48

−1.24

−1.61

0.5

 

hsa-miR-151a-5p

MIMAT0004697

−0.01

−1.21

1.35

−1.59

−2.01

−1.13

0.02

hsa-miR-195-5p

MIMAT0000461

−1.07

−1.27

0.53

1.22

1.13

1.45

0.005

hsa-miR-143-3p

MIMAT0000435

2.26

1.85

4.34

1.28

−0.5

2.15

 

hsa-miR-30d-5p

MIMAT0000245

0.02

−1.48

1.42

−1.14

−1.38

1.15

 

hsa-miR-191-5p

MIMAT0000440

−1.1

−1.24

1.23

−1.47

−1.73

0.53

 

hsa-let-7i-5p

MIMAT0000415

1.15

1.08

1.41

1.1

−1.16

1.32

 

hsa-miR-302a-3p

MIMAT0000684

−1.06

−1.19

1.4

−1.25

−1.85

1.13

 

hsa-miR-222-3p

MIMAT0000279

1.4

−0.53

1.85

−1.52

−1.65

0.55

<0.001

hsa-let-7b-5p

MIMAT0000063

1.14

−1.09

1.42

1.96

1.53

2.14

0.002

hsa-miR-19b-3p

MIMAT0000074

1.64

−1.4

3.14

0.07

−1.15

1.67

 

hsa-miR-17-5p

MIMAT0000070

1.63

1.26

2.28

−1.02

−1.32

1.3

0.002

hsa-miR-93-5p

MIMAT0000093

1.23

−1.18

2.45

0.01

−1.45

1.35

 

hsa-miR-186-5p

MIMAT0000456

−1.94

−2.44

−1.37

1.34

−0.54

1.64

<0.001**

hsa-miR-196b-5p

MIMAT0001080

1.46

−3.14

7.09

1.81

−1.24

6.42

 

hsa-miR-27a-3p

MIMAT0000084

1.33

−0.54

1.65

−1.04

−1.34

1.36

 

hsa-miR-22-3p

MIMAT0000077

2.42

1.44

4.24

1.35

−0.6

2.19

0.003

hsa-miR-130a-3p

MIMAT0000425

1.6

1.15

2.06

2.05

−0.6

3.12

 

hsa-let-7c

MI0000064

−1.2

−1.35

1.17

0.01

−1.08

1.57

 

hsa-miR-29c-3p

MIMAT0000681

1.41

−0.53

1.84

1.04

−1.34

1.25

 

hsa-miR-140-3p

MIMAT0004597

1.69

−0.57

3.06

−1.24

−1.62

1.1

0.008

hsa-miR-128-3p

MIMAT0000424

−1.18

−1.48

0.58

−1.44

−1.73

0.48

 

hsa-let-7f-5p

MIMAT0000067

−1.6

−1.91

−1.39

−1.4

−2.02

−1.14

 

hsa-miR-122-5p

MIMAT0000421

−1.84

−4.05

−1.01

1.65

−0.59

3.24

0.028

hsa-miR-20a-5p

MIMAT0000075

1.36

−0.53

2

−1.38

−1.56

0.53

0.004

hsa-miR-106b-5p

MIMAT0000680

2.06

−0.41

2.69

−0.03

−1.27

1.23

0.006

hsa-miR-7-5p

MIMAT0000252

−1.53

−2.98

−1.37

−1.45

−2.61

0.49

 

hsa-miR-100-5p

MIMAT0000098

−1.05

−1.36

1.19

−1.85

−2.09

1.05

 

hsa-miR-302c-3p

MIMAT0000717

−1.17

−1.74

3.62

1.9

1.2

2.27

 
  1. *Mann–Whitney U test.
  2. **When data was divided into low and high IL-6 stimulants, highly significant results (P < 0.001) were observed in the group of low IL-6 stimulants, like streptococci and P. gingivalis (see Figures 2 and 3).
  3. Fold changes calculated using unstimulated cells as a reference. The data from different stimuli (streptococci, P. gingivalis, A. actinomytectemcomititans or TNFα) were pooled and median values presented with 25th and 75th interquartile ranges. P-values < 0.05 are presented. P-values < 0.001 in bold.