From: Off-label use of cancer therapies in women diagnosed with breast cancer in the United States
Drug category | Drug name | Indicated for breast cancer | Labeled indications if not indicated for breast cancer (ICD-9 codes) | Initial FDA approval during study period |
---|---|---|---|---|
Alkylating agents | Carboplatin | 183, 198.6 | 1989 | |
Carmustine | 191,200-202,203.0 | 1977 | ||
Chlorambucil | 200-202,204.1,204.9 | 1957 | ||
Cisplatin | 183,186,188,198.6 | 1978 | ||
Cyclophosphamide | Yes | 1959 | ||
Dacarbazine | 172,198.2, 201 | 1975 | ||
Ifosfamide | 186 | 1988 | ||
Mechlorethamine | 162.2-162.5,162.8,162.9,197.0,200,201,202.0 | 1949 | ||
202.1,202.8,204.1,205.1,208.1,238.4,511.9 | ||||
Melphalan | 183,1 198.6, 1203.0 | 1964 | ||
Oxaliplatin | 153,154,197.5 | August 2002 | ||
Streptozocin | 157.4 | 1982 | ||
Thiotepa | Yes | 1959 | ||
Antimetabolites | Azacitidine | 205,280-285 | May 2004 | |
Capecitabine | Yes | 1998 | ||
Cladribine | 202.4 | 1993 | ||
Clofarabine | 204.0,204.9 | December 2004 | ||
Cytarabine | 204.0, 204.9, 205.0, 205.1, 205.9 | 1969 | ||
Fludarabine | 204.1, 204.9 | 1991 | ||
Fluorouracil | Yes | 1962 | ||
Gemcitabine | Yes2 | 157.0-157.9, 162.2-162.5, 162.8, 162.9, 197.03 | 1996 | |
Hydroxyurea | 172.1-172.4, 173.1-173.4, 183, 195.0, 198.2, 198.6, 205.1, 205.9 | 1967 | ||
Mercaptopurine | 204.0, 204.9 | 1953 | ||
Methotrexate | Yes | 1953 | ||
Pemetrexed | 162.2-162.5, 162.8, 162.9, 163, 197.0 | February 2004 | ||
Anti-tumor antibiotics | Bleomycin | 140-149, 160, 161, 180, 184, 186, 187, 195.0, 197.2, 198.82, 200–202, 511 | 1973 | |
Dactinomycine | Yes4 | 1964 | ||
Daunorubicin | 204.00-204.91, 205.00-205.21, 205.80-205.91, 208.00-208.01 | 1979 | ||
Doxorubicin | Yes | 1974 | ||
Epirubicin | Yes | 1974 | ||
Idarubicin | Yes | 1999 | ||
Liposomal doxorubicin | 205.0, 205.9 | 1990 | ||
Mitomycin-C | 151, 157 | 1981 | ||
Topoisomerase inhibitors | Etoposide | 162.2-162.5, 162.8, 162.9, 186, 197.0 | 1983 | |
Irinotecan | 153, 154, 197.5 | 1996 | ||
Mitoxantrone | 185, 205–208, 340 | 1987 | ||
Topotecan | 162.2-162.5, 162.8, 162.9, 180, 183,197.0, 198.6 | 1996 | ||
Anti-mitotic | Docetaxel | Yes | 1996 | |
Ixabepilone | Yes | October 2007 | ||
nab-Paclitaxel | Yes | January 2005 | ||
Paclitaxel | Yes | 1992 | ||
Vinblastine | Yes | 1965 | ||
Vincristine | 171, 189.0, 189.9, 194.0, 194.9, 198.0, 200, 201, 202.0, 202.1, 202.8, 204.0, 204.9 | 1963 | ||
Vinorelbine | 162.3-162.5, 162.8, 162.9 | 1994 |