Predictors of European League Against Rheumatism (EULAR) good response, DAS-28 remission and sustained responses to TNF-inhibitors in rheumatoid arthritis: a prospective study in refractory disease

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Table 4 The correlations between the different assessment parameters and the treatment outcome in the studied patients

Parameter	EULAR good response	Remission	Sustained response
Parameter	At 6 months	At 6 months	At 2 years
Disease duration	r = − 0.16	r = −0.05	r = − 0.10
Disease duration	P > 0.05	P > 0.05	P > 0.05
Positive IgM RF at baseline	r = 0.30	r = 0.31	r = 0.30
Positive IgM RF at baseline	P = < 0.05^*	P < 0.05^*	P < 0.05^*
Positive Anti-CCP at baseline	r = 0.18	r = 0.08	r = 0.14
Positive Anti-CCP at baseline	P > 0.05	P = 0.35	P > 0.05
Baseline Hemoglobin	r = 0.39	r = 0.30	r = 0.33
Baseline Hemoglobin	P < 0.05*	P < 0.05^*	P < 0.05^*
Baseline DAS 28	r = − 0.81	r = − 0.74	r = − 0.85
Baseline DAS 28	P < 0.01^**	P <0.01^**	P < 0.01^*
Baseline HAQ	r = − 0.08	r = − 0.18	r = − 0.74
Baseline HAQ	P > 0.05	P < 0.05^*	P < 0.01^**
Baseline VAS	r = 0.12	r = − 0.06	r = − 0.17
Baseline VAS	P > 0.05	P > 0.05	P > 0.05
Baseline Radiographic erosions	r = − 0.75	r = − 0.80	r = − 0.77
Baseline Radiographic erosions	P < 0.01^**	P = 0.01^**	P <0.01^**
Declining RF titers	r = 0.33	r = 0.30	r = 0.30
Declining RF titers	P <0.05*	P < 0.05*	P < 0.05*

*P-value: significant < 0.05. **P-value: highly significant < 0.01. Abbreviations: ESR: erythrocyte sedimentation rate, HAQ: health assessment questionnaire, DAS: disease activity score, VAS: visual analogue scale.