Table 1 Crude and adjusted hazard ratios (HR) with 95 % confidence interval (CI) for methotrexate restart after a treatment gab ≥ 90 days among 299 patients with rheumatoid arthritis in the County of Aarhus, Denmark 1998-2006

Gender

Male

203 (67.9)

1.3 (0.9;1.9)

1.3 (0.9;2.0)

Female

96 (32.1)

1

1

Age

<55 years

109 (36.5)

0.8 (0.5;1.3)

0.9 (0.6;1.7)

55-67 years

92 (30.7)

1

1

>67 years

98 (32.8)

0.7 (0.4;1.1)

0.7 (0.4;1.2)

C-reactive protein

< 75 nmol/L

154 (51.5)

1

1

76-300 nmol/L

78 (26.1)

1.0 (0.6;1.5)

1.1(0.7;1.8)

>300 nmol/L

60 (20.1)

0.5 (0.3;0.9)

0.6 (0.3;1.2)

Missing

7 (2.3)

-

-

Hemoglobin

Low

89 (29.8)

1.4 (0.9;2.2)

1.0 (0.6;1.8)

Normal

203 (67.9)

1

1

Missing

7 (2.3)

-

-

Co-morbidity

0

209 (69.9)

1

1

> = 1

90 (30.1)

0.8 (0.5;1.2)

0.8 (0.5;1.3)

Concurrent DMARD

Yes

110 (36.8)

0.7 (0.5;1.0)

0.8 (0.5; 1.2)

No

189 (63.2)

1

1

Corticosteroids

Yes

100 (33.4)

0.5 (0.3,0.7)

0.7 (0.4;1.1)

No

189 (66.6)

1

1