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Figure 1

From: Efficient in vivo antitumor effect of an immunotoxin based on ribotoxin α-sarcin in nude mice bearing human colorectal cancer xenografts

Figure 1

Immunotoxin inhibits colorectal tumor growth in vivo . A) Time course of the tumor volume progression of SW1222-derived xenografts non-treated (PBS) or treated with 50 or 100 μg IMTXA33αS (IMTX50 or IMTX100, respectively), 40 μg wild type α-sarcin or 61 μg scFvA33, per injection. α-Sarcin and scFvA33 doses were equivalent to the highest dose of immunotoxin used (IMTX100), 2.2 nanomoles in each case. The arrow indicates the beginning of treatment Doses were given every 48 hours. *, p < 0.05; **, p < 0.01; ***, p > 0.05 vs vehicle treated tumors. //, indicates suspension of treatment. B) Growth and C) weight measurements of excised tumors of non-treated (PBS) or after in vivo treatment with IMTXA33αS.

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