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Table 5 Comparison of the main clinical and pathological features of the two cases (DIC = disseminated intravascular coagulation; SLE = systemic lupus erythematosus)

From: Fatal Kikuchi-like lymphadenitis associated with connective tissue disease: a report of two cases and review of the literature

  Case 1 Case 2
Age and Gender 57 year old female. 55 year old female.
Past Medical History Mixed connective tissue disease - including arthritis, Raynaud’s phenomenon and rheumatoid nodules/granuloma annulare. Psoriasis. Multiple drug allergies. SLE/ Sjogren’s syndrome. Small fibre neuropathy. Asthma.
Clinical presentation No sun exposure. Pyrexia (38-40°C), flank pain, urinary frequency, erythematous rash on trunk. Deteriorated into sepsis-like clinical picture. Sun exposure. Pyrexia (40°C), non-blanching rash over upper arms and thighs, sepsis-like clinical picture.
Autoantibodies ANA with speckled pattern, anti-La and RNP. Anti-Ro and Anti-La.
Thrombocytopenia/DIC Yes Yes
Acidosis Yes Yes
Lymph node histology Necrotising lymphadenitis. Necrotising lymphadenitis.
Blood vessel thrombosis No Yes
Spleen involvement Yes No