Connective tissue disease predating necrotising lymphadenitis | ||||
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Country and reference | Age and gender | Connective tissue disease | Autoantibodies | Outcome |
Canada (Silver et al. 2004) | 43Â year old Female | Discoid lupus erythematosus for 10Â years | None | Recovered without treatment |
India (Londhey et al. 2010) | 39Â year old Female | SLE for 2Â years (not initially diagnosed) | ANA and anti-dsDNA | No life-threatening sequelae. Responded to corticosteroids and hydroxychloroquine. Asymptomatic at 1Â year follow-up. |
Canada (Pace-Asciak et al. 2008) | 35Â year old Female | SLE (duration not stated) | NA | Lymphadenitis resolved with conservative management. |
France (Frikha et al. 2008) | 30Â year old Female | Mixed connective tissue disease for 8Â years | ANA, anticardiolipin | Lymphadenitis resolved with corticosteroid therapy. |
Taiwan (Chen and Lan 1998) | 4 cases All female Ages 21–35 years old | SLE for 8 days to 2 years | Ribosomal-P antibodies (1 case) RNP (1 case) None (2 cases) | No life-threatening sequelae |
France (Abraham et al. 2011) | 35Â year old Female | Overlap syndrome for 12Â years | Antiphospholipid antibodies | Lymphadenitis resolved with corticosteroid therapy. |
Sabah (Bachi 2002) | 27 year old Female | SLE – systemic symptoms for 2 months | ANA, anti-Ro, anti-La at onset of lymphadenitis | Complete remission with corticosteroid therapy. |
Japan (Wano et al. 2000) | 37Â year old Female | SLE for 2Â years | NA | Haemophagocytic syndrome. Complete remission with corticosteroid pulse therapy. |
India (Londhey et al. 2010) | 39Â year old Female | Onset of connective tissue disease for 4Â years. Lymphadenitis first appeared after 2Â years. SLE diagnosis established later. | ANA, anti-dsDNA. | Complete remission with corticosteroid therapy. |
Spain (Sopena et al. 2012) | 2 cases 22 and 32Â years old Both Female | Both SLE. Onset not stated. | ANA only (1 case) ANA, anticardiolipin, anti-Ro, RNP (1 case) | Good response to therapy |
Italy (Ruaro et al. 2014) | 19 year old Male | SLE, onset 2–3 months prior to diagnosis of Kikuchi lymphadenitis | ANA only | Initial good response to therapy, single episode of relapse 2 years after initial onset, subsequently symptom free on corticosteroid and methotrexate therapy. |