Fatal Kikuchi-like lymphadenitis associated with connective tissue disease: a report of two cases and review of the literature

Sharma, Vijay; Rankin, Rosslyn

doi:10.1186/s40064-015-0925-7

SpringerPlus

Table 2 Clinical characteristics of previously reported cases of Kikuchi-Fujimoto disease occurring simultaneously with connective tissue disease

From: Fatal Kikuchi-like lymphadenitis associated with connective tissue disease: a report of two cases and review of the literature

Necrotising lymphadenitis occurring simultaneously with connective tissue disease
Country and reference	Age and gender	Connective tissue disease	Autoantibodies	Outcome
Greece (Gionanlis et al. 2009)	23 year old Female	SLE	ANA, anti-dsDNA, Anti-Ro, Anti-La, anti-RNP	Renal failure.TTP. Responded to immunosuppression + rituximab.
USA (Smith and Petri 2013)	27 year old Female	SLE	ANA, anti dsDNA, anticardiolipin IgG and IgM, anti-Smith, anti-Ro, anti-La.	Developed lupus nephritis. Condition stable.
Japan (Aota et al. 2009)	36 year old Male	SLE	ANA	Lymphadenitis resolved with corticosteroid therapy. Developed lupus nephritis. Condition stable at 4 month follow up.
France (Gallien et al. 2008)	47 year old Male	SLE	ANA, anti-dsDNA	Lymphadenitis resolved with corticosteroid therapy.
France (Frikha et al. 2008)	14 year old Female	SLE	ANA, anti-RNP, anti-Ro	Lymphadenitis resolved with corticosteroid therapy.
France (Frikha et al. 2008)	23 year old Female	SLE	ANA, anti-dsDNA, anti-Sm, anti-RNP, anti-Ro, anti-La.	Lymphadenitis resolved with corticosteroid therapy.
Germany (Hoffmann et al. 1991)	37 year old Male	SLE	HHV-6	No life-threatening sequelae.
England (Shusang et al. 2008)	20 year old Female	SLE Had 3 year history of autoimmune hepatitis	ANA (at onset of autoimmune hepatitis) Anti-Ro, anticardiolipin (at onset of SLE)	Lymphadenitis resolved with corticosteroid therapy.
Turkey (Yilmaz et al. 2006)	53 year old Female	SLE	ANA	No life-threatening sequelae.
Singapore (Chua et al. 1996)	9 year old Female	SLE with erythema multiforme	ANA, anti-dsDNA	No life-threatening sequelae.
USA (Eisner et al. 1996)	Young male	SLE	ANA	Concurrent lupus nephritis. Complete remission with corticosteroid therapy and cyclophosphamide.
France (Leyral et al. 2005)	26 year old Female	SLE	ANA, anti-dsDNA	Haemophagocytic syndrome with EBV infection. Complete remission with corticosteroids.
Romania (Tanasescu et al. 2003)	17 year old Female	SLE and autoimmune hepatitis	Anti-Sm	Complete remission with corticosteroid therapy
Brazil (Santana et al. 2005)	20 year old Female	SLE	ANA, anti-Ro, anticardiolipin	Lymphadenitis resolved with corticosteroid therapy.
Spain (Jimenez Saenz et al. 2001)	30 year old Female	SLE	ANA, anti-dsDNA, anti-RNP, anti-scl 70	Complete remission with corticosteroid therapy.
USA (Mahajan et al. 2007)	56 year old Female	SLE	ANA, anti-dsDNA	Partial improvement with hydroxychloroquine, followed by complete remission.
USA (Gordon et al. 2009)	33 year old Male	SLE	ANA, anti-Smith, anti-RNP, anti-Ro.	Complete remission with corticosteroid therapy.
Germany (Cramer et al. 2010)	33 year old Male	SLE	ANA, anti-dsDNA	Clinical improvement with corticosteroid and mycophenolate therapy.
USA (Quintas-Cardama et al. 2003)	38 year old Female	SLE	ANA	Severe auto-immune-related clinical sequelae and cardiogenic shock. Patient died despite pulse corticosteroid and cyclophosphamide therapy.
Spain (Sopena et al. 2012)	27 year old Female	SLE	ANA	Good response to therapy.
Spain (Diez-Morrondo et al. 2012)	22 year old Female	SLE	ANA	Good response to hydroxychloroquine.
Thailand (Kampitak 2008)	50 year old Male	SLE	ANA	Developed haemophagocytic syndrome and severe hospital acquired pneumonia and septic shock. Patient died.

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