Table 2 Clinical characteristics of previously reported cases of Kikuchi-Fujimoto disease occurring simultaneously with connective tissue disease
Necrotising lymphadenitis occurring simultaneously with connective tissue disease | ||||
|---|---|---|---|---|
Country and reference | Age and gender | Connective tissue disease | Autoantibodies | Outcome |
Greece (Gionanlis et al. 2009) | 23 year old Female | SLE | ANA, anti-dsDNA, Anti-Ro, Anti-La, anti-RNP | Renal failure.TTP. Responded to immunosuppression + rituximab. |
USA (Smith and Petri 2013) | 27 year old Female | SLE | ANA, anti dsDNA, anticardiolipin IgG and IgM, anti-Smith, anti-Ro, anti-La. | Developed lupus nephritis. Condition stable. |
Japan (Aota et al. 2009) | 36 year old Male | SLE | ANA | Lymphadenitis resolved with corticosteroid therapy. Developed lupus nephritis. Condition stable at 4 month follow up. |
France (Gallien et al. 2008) | 47 year old Male | SLE | ANA, anti-dsDNA | Lymphadenitis resolved with corticosteroid therapy. |
France (Frikha et al. 2008) | 14 year old Female | SLE | ANA, anti-RNP, anti-Ro | Lymphadenitis resolved with corticosteroid therapy. |
France (Frikha et al. 2008) | 23 year old Female | SLE | ANA, anti-dsDNA, anti-Sm, anti-RNP, anti-Ro, anti-La. | Lymphadenitis resolved with corticosteroid therapy. |
Germany (Hoffmann et al. 1991) | 37 year old Male | SLE | HHV-6 | No life-threatening sequelae. |
England (Shusang et al. 2008) | 20 year old Female | SLE Had 3 year history of autoimmune hepatitis | ANA (at onset of autoimmune hepatitis) Anti-Ro, anticardiolipin (at onset of SLE) | Lymphadenitis resolved with corticosteroid therapy. |
Turkey (Yilmaz et al. 2006) | 53 year old Female | SLE | ANA | No life-threatening sequelae. |
Singapore (Chua et al. 1996) | 9 year old Female | SLE with erythema multiforme | ANA, anti-dsDNA | No life-threatening sequelae. |
USA (Eisner et al. 1996) | Young male | SLE | ANA | Concurrent lupus nephritis. Complete remission with corticosteroid therapy and cyclophosphamide. |
France (Leyral et al. 2005) | 26 year old Female | SLE | ANA, anti-dsDNA | Haemophagocytic syndrome with EBV infection. Complete remission with corticosteroids. |
Romania (Tanasescu et al. 2003) | 17 year old Female | SLE and autoimmune hepatitis | Anti-Sm | Complete remission with corticosteroid therapy |
Brazil (Santana et al. 2005) | 20 year old Female | SLE | ANA, anti-Ro, anticardiolipin | Lymphadenitis resolved with corticosteroid therapy. |
Spain (Jimenez Saenz et al. 2001) | 30 year old Female | SLE | ANA, anti-dsDNA, anti-RNP, anti-scl 70 | Complete remission with corticosteroid therapy. |
USA (Mahajan et al. 2007) | 56 year old Female | SLE | ANA, anti-dsDNA | Partial improvement with hydroxychloroquine, followed by complete remission. |
USA (Gordon et al. 2009) | 33 year old Male | SLE | ANA, anti-Smith, anti-RNP, anti-Ro. | Complete remission with corticosteroid therapy. |
Germany (Cramer et al. 2010) | 33 year old Male | SLE | ANA, anti-dsDNA | Clinical improvement with corticosteroid and mycophenolate therapy. |
USA (Quintas-Cardama et al. 2003) | 38 year old Female | SLE | ANA | Severe auto-immune-related clinical sequelae and cardiogenic shock. Patient died despite pulse corticosteroid and cyclophosphamide therapy. |
Spain (Sopena et al. 2012) | 27 year old Female | SLE | ANA | Good response to therapy. |
Spain (Diez-Morrondo et al. 2012) | 22 year old Female | SLE | ANA | Good response to hydroxychloroquine. |
Thailand (Kampitak 2008) | 50 year old Male | SLE | ANA | Developed haemophagocytic syndrome and severe hospital acquired pneumonia and septic shock. Patient died. |