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Table 2 Clinical characteristics of previously reported cases of Kikuchi-Fujimoto disease occurring simultaneously with connective tissue disease

From: Fatal Kikuchi-like lymphadenitis associated with connective tissue disease: a report of two cases and review of the literature

Necrotising lymphadenitis occurring simultaneously with connective tissue disease
Country and reference Age and gender Connective tissue disease Autoantibodies Outcome
Greece (Gionanlis et al. 2009) 23 year old Female SLE ANA, anti-dsDNA, Anti-Ro, Anti-La, anti-RNP Renal failure.TTP. Responded to immunosuppression + rituximab.
USA (Smith and Petri 2013) 27 year old Female SLE ANA, anti dsDNA, anticardiolipin IgG and IgM, anti-Smith, anti-Ro, anti-La. Developed lupus nephritis. Condition stable.
Japan (Aota et al. 2009) 36 year old Male SLE ANA Lymphadenitis resolved with corticosteroid therapy. Developed lupus nephritis. Condition stable at 4 month follow up.
France (Gallien et al. 2008) 47 year old Male SLE ANA, anti-dsDNA Lymphadenitis resolved with corticosteroid therapy.
France (Frikha et al. 2008) 14 year old Female SLE ANA, anti-RNP, anti-Ro Lymphadenitis resolved with corticosteroid therapy.
France (Frikha et al. 2008) 23 year old Female SLE ANA, anti-dsDNA, anti-Sm, anti-RNP, anti-Ro, anti-La. Lymphadenitis resolved with corticosteroid therapy.
Germany (Hoffmann et al. 1991) 37 year old Male SLE HHV-6 No life-threatening sequelae.
England (Shusang et al. 2008) 20 year old Female SLE Had 3 year history of autoimmune hepatitis ANA (at onset of autoimmune hepatitis) Anti-Ro, anticardiolipin (at onset of SLE) Lymphadenitis resolved with corticosteroid therapy.
Turkey (Yilmaz et al. 2006) 53 year old Female SLE ANA No life-threatening sequelae.
Singapore (Chua et al. 1996) 9 year old Female SLE with erythema multiforme ANA, anti-dsDNA No life-threatening sequelae.
USA (Eisner et al. 1996) Young male SLE ANA Concurrent lupus nephritis. Complete remission with corticosteroid therapy and cyclophosphamide.
France (Leyral et al. 2005) 26 year old Female SLE ANA, anti-dsDNA Haemophagocytic syndrome with EBV infection. Complete remission with corticosteroids.
Romania (Tanasescu et al. 2003) 17 year old Female SLE and autoimmune hepatitis Anti-Sm Complete remission with corticosteroid therapy
Brazil (Santana et al. 2005) 20 year old Female SLE ANA, anti-Ro, anticardiolipin Lymphadenitis resolved with corticosteroid therapy.
Spain (Jimenez Saenz et al. 2001) 30 year old Female SLE ANA, anti-dsDNA, anti-RNP, anti-scl 70 Complete remission with corticosteroid therapy.
USA (Mahajan et al. 2007) 56 year old Female SLE ANA, anti-dsDNA Partial improvement with hydroxychloroquine, followed by complete remission.
USA (Gordon et al. 2009) 33 year old Male SLE ANA, anti-Smith, anti-RNP, anti-Ro. Complete remission with corticosteroid therapy.
Germany (Cramer et al. 2010) 33 year old Male SLE ANA, anti-dsDNA Clinical improvement with corticosteroid and mycophenolate therapy.
USA (Quintas-Cardama et al. 2003) 38 year old Female SLE ANA Severe auto-immune-related clinical sequelae and cardiogenic shock. Patient died despite pulse corticosteroid and cyclophosphamide therapy.
Spain (Sopena et al. 2012) 27 year old Female SLE ANA Good response to therapy.
Spain (Diez-Morrondo et al. 2012) 22 year old Female SLE ANA Good response to hydroxychloroquine.
Thailand (Kampitak 2008) 50 year old Male SLE ANA Developed haemophagocytic syndrome and severe hospital acquired pneumonia and septic shock. Patient died.