Rapamycin increases expression of Foxo and Sirtuin genes in females but not in males. The effect of dietary restriction (DR) and rapamycin (Rapa) on the expression of Foxo and Sirtuin genes was measured in liver samples from female (A) and male (B) mice. Open bars: AL; solid bars: DR; Gray bars: Rapa 14 ppm. The data were obtained from 6 male and 8 female mice per group and expressed as mean ± SEM. An asterisk denotes values that are significantly different (p ≤ 0.05) from AL mice.