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Table 5 Outcomes renal cell carcinoma

From: Clinical characteristics and treatment-related biomarkers associated with response to high-dose interleukin-2 in metastatic melanoma and renal cell carcinoma: retrospective analysis of an academic community hospital’s experience

 

Clinical benefit (n=2)

No clinical benefit (n=11)

p-value

Total Doses

46.5 (38.0)

14.0 (10.0 – 22.0)

<.026*

Total Cycles

6.0 (6.0)

2.0 (2.0 – 4.0)

<.026*

Doses per Cycle

7.75 (6.33)

5.5 (5.0 – 6.75)

.231*

Duration (months)

28.0 (23.0)

2.0 (0 – 4.5)

<.026*

Peak Fever (Celsius)

39.3 (39.1 – 39.6)

38.9 (38.7 – 39.8)

.641*

Peak ALC

5.3 (5.1)

3.4 (2.0 – 4.6)

.103*

Platelets

49.0 (33.0)

109.0 (88.0 – 146.0)

.026*

Autoimmune phenomenon

1 (50.0%)

1 (9.1%)

.295

Any Toxicity

2 (100%)

3 (27.3%)

.128

None

0

8 (72.7%)

.128

Grade 3

2 (100%)

2 (18.2%)

.077

Grade 4

0

1 (9.1%)

.1.0

Grade 5

--

--

--

Survived

1 (50.0%)

6 (54.5%)

1.0

Survival Months

48.0

17.0

.231¥

  1. Fisher’s Exact test (reported as frequency (percent)).
  2. *Mann–Whitney U (reported as median (interquartile range)).
  3. ¥Log-Rank Test (reported as median, censored data included).
  4. ALC: Absolute Lymphocyte Count.