RAD51, XRCC3, and XRCC2 mutation screening in Finnish breast cancer families

Pelttari, Liisa M; Kiiski, Johanna I; Ranta, Salla; Vilske, Sara; Blomqvist, Carl; Aittomäki, Kristiina; Nevanlinna, Heli

doi:10.1186/s40064-015-0880-3

SpringerPlus

Table 3 SNPs from the haplotype analysis with ORs and p -values for breast cancer association

From: RAD51, XRCC3, and XRCC2 mutation screening in Finnish breast cancer families

Gene	rs-number	HGVS	MAF _controls	MAF _cases	OR	95% CI	p- value
RAD51	rs1801320	c.-98G > C	0.09	0.07	0.82	0.66-1.01	0.184
RAD51	rs3092981	c.-3 + 102C > T	0.17	0.18	1.07	0.91-1.27	0.614
RAD51	rs5030791	c.-3 + 203G > T	0.03	0.02	0.83	0.59-1.18	0.583
RAD51	rs2619681	c.-3 + 1398 T > C	0.18	0.17	0.88	0.75-1.05	0.352
RAD51	rs2304579	c.87 + 110A > G	0.09	0.07	0.82	0.67-1.01	0.184
RAD51	rs4924496	c.225 + 1936 T > C	0.29	0.29	1.06	0.90-1.24	0.549
RAD51	rs45503494	c.343 + 494 T > C	0.09	0.07	0.82	0.67-1.02	0.205
RAD51	rs45455000	c.344-36 T > G	0.09	0.07	0.82	0.67-1.02	0.202
RAD51	rs12592524	c.435 + 2149G > A	0.30	0.30	1.07	0.91-1.25	0.518
RAD51	rs4144242	c.436-4016G > A	0.09	0.07	0.82	0.67-1.02	0.202
RAD51	rs4924500	c.530 + 4654A > G	0.18	0.17	0.88	0.74-1.04	0.314
RAD51	rs45532539	c.531-3201G > T	0.004	0.009	1.92	0.97-4.10	0.062
RAD51	rs45507396	c.*929A > G	0.09	0.07	0.82	0.66-1.01	0.187
RAD51	rs45585734	c.*1113C > G	0.09	0.07	0.82	0.66-1.01	0.187
XRCC3	rs861539	c.722C > T	0.32	0.33	1.06	0.90-1.24	0.489
XRCC3	rs861537	c.562-1162G > A	0.29	0.26	0.89	0.76-1.04	0.060
XRCC3	rs861536	c.562-1651 T > C	0.32	0.33	1.06	0.90-1.24	0.475
XRCC3	rs12432907	c.561 + 1132G > A	0.23	0.21	0.92	0.78-1.08	0.092
XRCC3	rs3212092	c.561 + 866C > T	0.004	0.002	0.57	0.20-1.51	0.246
XRCC3	rs3212081	c.407-478G > A	0.005	0.006	1.15	0.55-2.49	0.704
XRCC3	rs3212079	c.407-801C > T	0.04	0.04	0.97	0.73-1.28	0.951
XRCC3	rs861531	c.406 + 533G > T	0.32	0.33	1.06	0.90-1.24	0.459
XRCC3	rs3212042	c.56-652G > A	0.03	0.04	1.17	0.86-1.58	0.456
XRCC3	rs3212028	c.-261 + 1368G > A	0.11	0.11	1.07	0.88-1.29	0.427
XRCC2	rs3218552	c.*1874G > A	0.02	0.02	0.95	0.66-1.37	0.879
XRCC2	rs3218550	c.*1772G > A	0.02	0.02	1.07	0.74-1.55	0.729
XRCC2	rs3218536	c.563G > A	0.04	0.05	1.08	0.82-1.43	0.256
XRCC2	rs3218504	c.122-4868C > T	0.02	0.02	0.94	0.65-1.36	0.878
XRCC2	rs6964582	c.122-5014G > C	0.02	0.02	1.02	0.70-1.47	0.676
XRCC2	rs3218501	c.122-5469C > G	0.02	0.02	0.93	0.64-1.34	0.839
XRCC2	rs3218491	c.121 + 4038A > G	0.02	0.02	1.04	0.72-1.52	0.817
XRCC2	rs3111465	c.40-4608 T > C	0.02	0.02	1.02	0.70-1.48	0.676
XRCC2	rs3094406	c.40-4998G > C	0.04	0.05	0.99	0.76-1.30	0.252
XRCC2	rs3218408	c.39 + 5510 T > G	0.23	0.23	1.09	0.93-1.28	0.447

The SNPs are presented in the same order as in the haplotypes in Table 2.

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