From: PNPLA3 I148M associations with liver carcinogenesis in Japanese chronic hepatitis C patients
 | Patients with HCC | Patients without HCC | Comparison between patients with HCC and those without HCC | Multiple regression analysis for factors associated with HCC development | |
---|---|---|---|---|---|
(n = 31) | (n = 106) | Odds ratio (95% confidence interval) | p | ||
Age (yrs) | 70.9±7.1 | 62.3±11.9 | P = 0.0002 | 1.09 (1.04 - 1.15) | p = 0.0006 |
Gender (male/female) | 16/15 | 48/58 | NS | Â | NS |
BMI (kg/m2) | 23.1±4.0 | 21.9±3.4 | NS |  |  |
PNPLA3 (GG/CC・CG) | 8/23 | 14/92 | P = 0.0928 |  | NS |
AST (IU/L) | 80.7±64.3 | 51.4±41.8 | P = 0.0032 |  |  |
ALT (IU/L) | 65.5±50.0 | 63.9±84.1 | NS |  |  |
γ-GTP (IU/L) | 53.5±40.7 | 60.0±73.6 | NS |  |  |
Albumin (g/dL) | 3.4±0.56 | 4.2±0.5 | p < 0.0001 |  |  |
Total bilirubin (mg/dL) | 1.5±1.1 | 0.8±0.4 | p < 0.0001 |  |  |
Platelet count (x104/μL) | 9.2±4.3 | 14.1±5.5 | P = 0.0008 |  |  |
Prothrombin time (%) | 81.5±14.0 | 96.0±19.7 | P= 0.0002 |  |  |
Hyaluronic acid (ng/mL) | 507.0±542.5 | 202.1±313.7 | P = 0.0002 |  |  |
α-fetoprotein (ng/mL) | 475.9±1411.2 | 28.7±148.1 | P = 0.0016 |  |  |
PIVKA-II(mAU/mL) | 47.0±51.0 | 20.8±10.7 | p < 0.0001 |  |  |
HCV genotype (1/2/3) | 27/4/0 | 82/23/1 | NS | Â | Â |
HCV RNA (log IU/mL) | 5.9±1.0 | 6.2±0.9 | NS |  |  |
Velocity of shear wave (m/s) | 2.20±0.70 | 1.55±0.50 | p < 0.0001 |  |  |