Table 3 Comparison between the patients with Vs < 1.55 m/s and those with Vs ≧ 1.55 m/s in the 137 patients without past history of IFN treatment
From: PNPLA3 I148M associations with liver carcinogenesis in Japanese chronic hepatitis C patients
Patients with Vs ≧ 1.55 m/s | Patients with Vs < 1.55 m/s | Comparison between patients with Vs < 1.55 m/s and those with Vs ≧ 1.55 m/s | Multiple regression analysis for factors associated with ≧ 1.55 m/s | ||
|---|---|---|---|---|---|
(n = 72) | (n = 65) | Odds ratio (95% confidence interval) | p | ||
Age (yrs) | 67.3±10.3 | 60.9±12.0 | P = 0.0011 | 1.05 (1.02 - 1.09) | p = 0.0034 |
Gender (male/female) | 33/39 | 31/34 | NS | NS | |
BMI (kg/m2) | 22.6±3.6 | 21.7±3.4 | NS | ||
PNPLA3 (GG/CC・CG) | 17/55 | 5/60 | P = 0.0113 | 3.35 (1.13 - 9.91) | p = 0.0291 |
AST (IU/L) | 76.7±56.2 | 37.3±28.4 | p < 0.0001 | ||
ALT (IU/L) | 82.9±96.2 | 43.6±41.1 | P = 0.0027 | ||
γ-GTP (IU/L) | 64.0±57.3 | 51.9±77.1 | NS | ||
Albumin (g/dL) | 3.7±0.6 | 4.3±0.4 | p < 0.0001 | ||
Total bilirubin (mg/dL) | 1.1±0.7 | 0.8±0.6 | P = 0.0078 | ||
Platelet count (x104/μL) | 10.4±4.5 | 15.9±5.3 | p < 0.0001 | ||
Prothrombin time (%) | 87.1±15.4 | 99.1±21.5 | P = 0.0002 | ||
Hyaluronic acid (ng/mL) | 385.0±383.0 | 148.8±371.4 | P = 0.0006 | ||
α-fetoprotein (ng/mL) | 233.9±939.1 | 6.8±10.8 | P = 0.0553 | ||
PIVKA-II(mAU/mL) | 32.9±36.1 | 20.0±11.9 | P = 0.0072 | ||
HCV genotype (1/2/3) | 61/10/1 | 48/17/0 | NS | ||
HCV RNA (log IU/mL) | 6.0±0.9 | 6.2±1.3 | NS | ||
Velocity of shear wave (m/s) | 2.14±0.46 | 1.23±1.0 | p < 0.0001 | ||
Hepatocellular carcnoma (present/absent) | 28/44 | 3/62 | p < 0.0001 | ||