Table 3 Results of univariate and multivariate survival analysis at 10-year follow up

LNR

≤0.20

1.00

1.00

92

1.00

93

1

>0.2–0.65

2.91 (1.90–4.47)

<.001

2.20 (1.09–4.41)

0.027

59

1.94 (0.91–4.12)

0.085

38

1.05 (0.20–5.54)

0.957

>0.65

4.31 (2.56–7.25)

<.001

3.07 (1.21–7.80)

0.018

21

2.03 (0.56–7.33)

0.282

18

2.64 (0.39–18.04)

0.322

pN stage

pN1 (1–3)

1.00

1.00

118

1.00

88

1

pN2 (4–9)

2.52 (1.62–3.91)

<.001

1.28 (0.63–2.60)

0.500

44

1.15 (0.51–2.60)

0.745

30

4.31 (0.88–21.20)

0.073

pN3 (≥10)

3.85 (2.38–6.21)

<.001

1.31 (0.56–3.08)

0.533

10

1.03 (0.23–4.64)

0.970

31

5.03 (0.86–29.45)

0.073

Age at diagnosis

<40

1.68 (0.99–2.86)

0.056

1.82 (1.03–3.22)

0.038

15

1.49 (0.61–3.66)

0.384

18

3.43 (1.53–7.69)

0.003

≥40

1.00

1.00

157

1.00

131

1.00

Tumour size, mm

1–20

1.00

1.00

83

1.00

72

1.00

>20

2.25 (1.51–3.37)

<.001

1.52 (0.99–2.35)

0.058

89

1.95 (1.08–3.51)

0.027

77

0.76 (0.35–1.64)

0.487

Histological grade

1

1.00

1.00

22

1.00

20

1.00

2

2.16 (0.97–4.83)

0.060

1.84 (0.81–4.18)

0.143

58

2.18 (0.63–7.60)

0.221

62

1.79 (0.57–5.60)

0.318

3

3.21 (1.46–7.05)

0.004

2.21 (0.98–4.95)

0.055

77

3.73 (1.13–12.32)

0.031

53

1.40 (0.42–4.60)

0.584

Unknown

1.35 (0.45–4.02)

0.590

1.03 (0.34–3.11)

0.958

15

1.51 (0.30–7.60)

0.619

14

0.73 (0.15–3.69)

0.706

ER

Negative

1.00

1.00

11

1.00

13

1.00

Positive

0.37 (0.18–0.77)

0.008

0.49 (0.23–1.06)

0.071

36

0.59 (0.19–1.87)

0.367

35

0.20 (0.06–0.65)

0.007

Unknown

0.59 (0.32–1.09)

0.091

0.60 (0.32–1.13)

0.115

125

0.76 (0.29–1.95)

0.562

101

0.26 (0.10–0.66)

0.005

Chemotherapy

No

1.00

1.00

96

1.00

61

1.00

Yes

1.58 (1.05–2.37)

0.028

1.04 (0.67–1.61)

0.860

76

1.24 (0.69–2.22)

0.480

85

0.61 (0.29–1.30)

0.202