Representative staining of ER, PgR and AR in patients pre, during and post EE2 treatment. A: Staining in patient 4, who responded to EE2. Before EE2 treatment, ER staining was high, PgR staining was low and AR staining was only observed in the nucleus. After administration of EE2, ER decreased, PgR was increased and AR in the nucleus reduced while cytosolic staining increased. B: Staining in patient 3, who did not respond to EE2. Before EE2 treatment, high ER, low PgR and high nuclear AR were observed, while after EE2, ER was dramatically decreased as in patient 4. However, PgR was not induced and nuclear AR was decreased and not translocated to the cytosol.