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Table 1 Effects of aminobisphosphonates on bone resorption and CK activities in rabbit bone cells culture

From: Induction of creatine kinase release from cultured osteoclasts via the pharmacological action of aminobisphosphonates

Treatment Concentration of N-BP (μmol/L) CTX-1 CK activity (U/L)
  Concentration (nmol/L) % Inhibition
Control - 201.1 ± 8.5 - 9.7 ± 0.3
Alendronate 3 135.1 ± 6.5 32.8 10.0 ± 0.2
10 58.1 ± 6.0 71.1 12.2 ± 0.4#
30 25.8 ± 1.4 87.2 13.3 ± 0.6#
Risedronate 1 89.4 ± 5.9 55.5 10.8 ± 0.4
3 37.5 ± 3.8 81.4 12.6 ± 0.2#
10 17.4 ± 2.2 91.3 16.4 ± 0.6#
Minodronic acid 0.3 61.8 ± 4.0 69.3 15.9 ± 0.8#
1 25.8 ± 4.6 87.2 22.5 ± 1.4#
3 6.5 ± 1.0 96.8 25.0 ± 0.7#
  1. Values represents the mean ± SE of 8 individual cultures.
  2. #Significantly different from control group (p < 0.05).