Table 1 Effects of aminobisphosphonates on bone resorption and CK activities in rabbit bone cells culture
Treatment | Concentration of N-BP (μmol/L) | CTX-1 | CK activity (U/L) | |
|---|---|---|---|---|
Concentration (nmol/L) | % Inhibition | |||
Control | - | 201.1 ± 8.5 | - | 9.7 ± 0.3 |
Alendronate | 3 | 135.1 ± 6.5 | 32.8 | 10.0 ± 0.2 |
10 | 58.1 ± 6.0 | 71.1 | 12.2 ± 0.4# | |
30 | 25.8 ± 1.4 | 87.2 | 13.3 ± 0.6# | |
Risedronate | 1 | 89.4 ± 5.9 | 55.5 | 10.8 ± 0.4 |
3 | 37.5 ± 3.8 | 81.4 | 12.6 ± 0.2# | |
10 | 17.4 ± 2.2 | 91.3 | 16.4 ± 0.6# | |
Minodronic acid | 0.3 | 61.8 ± 4.0 | 69.3 | 15.9 ± 0.8# |
1 | 25.8 ± 4.6 | 87.2 | 22.5 ± 1.4# | |
3 | 6.5 ± 1.0 | 96.8 | 25.0 ± 0.7# | |