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Table 1 Case reports published describing an overlap between ANCA associated vasculitis and rheumatoid arthritis

From: Association of ANCA associated vasculitis and rheumatoid arthritis: a lesser recognized overlap syndrome

Year/Cases Diagnoses Age RA Age VAS Vasculitis symptoms Positive antibodies RA therapy Follow-up
1974/1 (Pritchard 1976) RA/GPA 40 59 ENT RhF, ANA Gold, tuberculin injections, NSAID D
1976/2 (Ohashi et al. 1992) RA/GPA 45 45 ENT RhF HCQ, aspirin I
RA/GPA 73 75 ENT, Eyes, Lung RhF Gold, NSAID I
11992/1 (Steuer et al. 1995) RA/GPA 33 38 ENT RhF NSAID, Gold I
1995/1 (Harper et al. 1997) RA/MPA 49 62 Lung,Kidney RhF, ANA, p-ANCA NSAID, Gold, SFZ I
1997/10 (Messiaen et al. 1998) RA/MPA 31-62 NA 5: kidney only 4: p-ANCA 6: NSAID 4 D
1: kidney, lung, eye 9: RhF 1: NSAID, Penicillamine HCQ 2 HD
3: kidney, skin 6: ANA 1: Prednisone, SFZ, Gold 4 I
1:kidney, bowel, skin 1: HCQ
1: HCQ, SFZ
1999/1 (Yorioka et al. 1999) RA/MPA 22 24 Kidney RhF, ANA, MPO-ANCA NSAID I
2002/2 (Chinoy & McKenna 2002) RA/GPA 32 32 ENT, Lung, Kidney p-ANCA Prednisolone, NSAID, CYC I
RA/GPA *41 26 Lung p-ANCA I
2003/2 (Douglas et al. 2003) RA/GPA 36 37 ORL, Lung, Kidney RhF, PR3-ANCA Prednisolone, MTX, NSAID. I
RA/GPA 35 55 Lung RhF, PR3-ANCA NSAID, MTX I
2005/1 (Goto et al. 2005) RA/MPA 44 48 ORL, eyes, Kidney MPO-ANCA, RhF, ANA MTX, Penicillamine, Gold, prednisolone I
2008/1 (Pai & Panda 2008) RA/GPA 57 60 Lung RhF, Anti-CCP, PR3-ANCA HCQ, prednisolone I
2012/4 (Szilasi et al. 2012) RA/GPA 40 70 Lung, Kidney PR3-ANCA, Anti-CCP,RhF Prednisolone I
RA/MPA *49 44 Lung, Kidney MPO-ANCA, RhF Adalimumab, RTX I
RA/MPA 28 34 Lung, Kidney MPO-ANCA, RhF Prednisone, SFZ, MTX I
RA/EGPA 52 54 Skin MPO-ANCA, RhF MTX, Cyclosporine I
2012/1 (Vaishnav et al. 2012) RA/GPA 36 37 Lung c-ANCA, RhF   D
2013/1 (Reitblat & Reitblat 2013) RA/GPA 45 58 Kidney PR3-ANCA, RhF MTX, Etanercept HD
2014/1 (Ortiz-Sierra et al. 2014) RA/GPA 65 67 Skin, lung, ENT, eye RhF, c-ANCA MTX, Prednisone, etanercept, I
Our report 5 RA/MPA 24-63 63-69 1: Kidney, lung 3: RhF 1: MTX, prednisone 5 I
1 RA/GPA 5: Kidney 1: Anti-CCP 1: SFZ 1 HD
1: PR3-ANCA 1: HCQ, MTX, leflunomide 1D
3: MPO-ANCA 1: Infliximab, MTX, SFZ
1: Etanercept, MTX, SFZ, AZA
1: Prednisolone
  1. RA: Rheumatoid Arthritis, GPA: Granulomatosis with polyangiitis, MPA: Microscopic polyangiitis, EGPA (Churg-Strauss Syndrome), ENT: ear, nose and throat; HCQ: hydroxychloroquine, NSAID: non-steroidal anti-inflammatory drug, CP: cyclophophamide; AZA: Azathioprine, SFZ: sulfasalazine, MTX: methotrexate, D: dead, I: AAV improved, HD: Hemodialysis.