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Table 1 IC 50 values for KYNA production and KYN uptake using 10 selected amino acids

From: Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro

Amino acids IC 50 for KYNA production (μmol/L) IC 50 for KYN uptake (μmol/L)
Leucine 36.9 30.4
Isoleucine 60.1 83.6
Phenylalanine 22.5 10.4
Methionine 184 98.6
Tyrosine 970 159
Cysteine 110
Glutamate 94.9
Alanine 146
Aspartate 502
Glutamine 647