Figure 3From: Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro Dose-dependent inhibition of tissue KYN concentration in tissue slices from cerebral cortex by (a) leucine (Leu), (b) isoleucine (Ile), (c) phenylalanine (Phe), (d) tyrosine (Tyr), (e) methionine (Met), (f) cysteine (Cys), (g) aspartate (Asp), (h) glutamine (Gln), (i) alanine (Ala), and (j) glutamate (Glu). Experiments were performed as described in the text using 2 μmol/L KYN. KYN was measured in tissue slice suspension. Values are expressed as mean ± SE (n = 4–6). Sigmoid curves were generated by nonlinear regression analysis using Graph Pad Prism 5.0.Back to article page