TY - JOUR AU - Sévère, Sabine AU - Marchand, Philippe AU - Guiffard, Ingrid AU - Morio, Floriane AU - Venisseau, Anaïs AU - Veyrand, Bruno AU - Le Bizec, Bruno AU - Antignac, Jean-Philippe AU - Abadie, Jérôme PY - 2015 DA - 2015/01/22 TI - Pollutants in pet dogs: a model for environmental links to breast cancer JO - SpringerPlus SP - 27 VL - 4 IS - 1 AB - Invasive breast carcinoma is the most common cancer in women as in non-ovariectomised pet dogs, which are already identified as a valuable spontaneous preclinical model for that disease. Geographical and time trends suggest that environmental factors may play an important role in the etiology and pathogenesis of breast cancer. Persistent organic pollutants (POPs) fit perfectly with these trends and are known to interact with hormonal receptors implicated in breast cancer subtyping. The aim of this innovating study was to evaluate the interest of the companion dog model in assessing chemical exposure and breast cancer associations, in order to identify common etiological features with the human disease in a context of comparative oncology. SN - 2193-1801 UR - https://doi.org/10.1186/s40064-015-0790-4 DO - 10.1186/s40064-015-0790-4 ID - Sévère2015 ER -