Table 1 Characteristics of individuals with breast cancer at time of diagnosis, screened for the CHEK2 1100delC mutation
Characteristics | Samples |
|---|---|
Cases/Controls | 134 / 114 |
Age at diagnosis, mean ± SD (years) | 41 ± 11 |
Range (years) | 23– 67 |
Menopausal status | No. (%) |
Premenopausal | 76(56.71) |
Postmenopausal | 57(42.53) |
Missing | 1(0.74) |
Estrogen receptor | |
Positive | 100 (74.62) |
Negative | 24(17.91) |
Missing | 10 (7.46) |
Progesterone receptor | |
Positive | 98 (73.13) |
Negative | 30(22.38) |
Missing | 6 (4.47) |
Estrogen/Progesterone receptor | |
ER + /PR + | 66 (49.25) |
ER + /PR − | 15 (11.19) |
ER − /PR + | 10 (7.46) |
ER − /PR − | 43 (32.08) |
Tumor size | |
<2 cm | 20 (14.92) |
>2 cm | 56 (41.79) |
>5 cm | 31(23.13) |
Tumor of any size with extension | 27 (20.14) |
Histological grade | |
1 | 8 (5.97) |
2 | 87 (64.92) |
3 | 39 (29.10) |
Lymph node status | |
Negative | 56(41.79) |
Positive | 78 (58.20) |
Distant metastases | |
Negative | 106(79.10) |
Positive | 28 (20.89) |