Skip to main content
  • Poster presentation
  • Open access
  • Published:

sRage plasma level in association with multiple sclerosis risk in Slovak population

Receptor for advanced glycation end products (RAGE) triggers an intracellular signalling pathways of various proinflammatory ligands. Solubile form of RAGE (sRAGE) in human plasma can hinder the function of RAGE and can have the role in the pathogenesis of inflammatory diseases. In patients with multiple sclerosis (MS), altered level of sRAGE in plasma and cerebrospinal fluid has been found. In our study, we tried to identify possible association of sRAGE serum level with MS. Serum levels of sRAGE were detected by ELISA in 44 MS patients (22 patients with rapid progression of MS and 22 patients with slow progression of MS according to the MSSS score) and 32 healthy control subjects. We found significantly increased level of sRAGE in serum of MS patients when compared to controls. No significant differences in serum level of sRAGE where found between rapidly progressing and slow progressing subgroup of MS patients. Our results suggest for the role of sRAGE in MS ethiopathogenesis, but we did not find any association of sRAGE in serum with the rate of MS disability progression.

Acknowledgements

This work was supported by the grant MZ SR No2012/30-UKMA-7 Biological and molecular markers of MS and by the grant MZ SR No2012/31-UKMA-8.

Author information

Authors and Affiliations

Authors

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dobrota, D., Cierny, D., Michalik, J. et al. sRage plasma level in association with multiple sclerosis risk in Slovak population. SpringerPlus 4 (Suppl 1), P10 (2015). https://doi.org/10.1186/2193-1801-4-S1-P10

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/2193-1801-4-S1-P10

Keywords