Volume 4 Supplement 1

European Society for Neurochemistry Biannual Conference: Molecular Mechanisms of Regulation in the Nervous System

Open Access

Characterization of neuropeptides which control cerebellar granule cell survival, migration and differentiation

  • David Vaudry1,
  • Auriane Corbière1,
  • Magalie Basille1,
  • Seyma Bahdoudi1,
  • Olfa Masmoudi2,
  • Jérome Leprince1,
  • Delphine Burel1,
  • Magalie Bénard3,
  • Ludovic Galas3 and
  • France Hitoshi Komuro4
SpringerPlus20154(Suppl 1):L58

https://doi.org/10.1186/2193-1801-4-S1-L58

Published: 12 June 2015

Keywords

cerebellar granule neuronsneuropeptidesbrain development

During cerebellar development, granule cell precursors are produced from a secondary germinative zone forming the external granule cell layer (EGL). Immature granule neurons from the inner part of the EGL then start a tangential migration followed by a centripetal inward radial migration across the molecular and Purkinje cell layers to reach their final destination at the bottom of the forming internal granule cell layer (IGL). This complex migratory process is highly regulated and takes about 2 days in rodents and it is essential for the proper formation of the cortical layers forming the mature cerebellum. In the IGL, granule cells differentiate to establish functional excitatory synapses with GABAergic neurons including Purkinje, basket, stellate and Golgi cells, or die. Some neurotrophins and neurotransmitters have been shown to be involved in the control of cerebellar granule cell survival, migration and differentiation. Initially, when I started my carrier as a researcher, we used to claim that very few neuropeptides were produced in the cerebellum. Nevertheless, we now know that this was wrong as we have recently identified by mass spectrometry over 70 peptides expressed in the cerebellum during development. Over the years, the involvement of some of these peptides such as somatostatin, PACAP or ODN, has been established in the control of cerebellar granule cell survival, migration and differentiation as will illustrate my presentation.

Declarations

Acknowledgements

Supported by INSERM, Rouen University, Interreg PeReNE and Région Haute-Normandie.

Authors’ Affiliations

(1)
INSERM U982, Rouen University
(2)
Tunis University
(3)
PRIMACEN, INSERM
(4)
Yale University

Copyright

© Vaudry et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.