Volume 4 Supplement 1

European Society for Neurochemistry Biannual Conference: Molecular Mechanisms of Regulation in the Nervous System

Open Access

Tau regulates the localization and function of End Binding proteins in neuronal cells

  • Carmen Laura Sayas1, 2, 3,
  • Elena Tortosa1,
  • Flavia Bollati1,
  • Sacnicte Ramírez-Ríos1,
  • Isabelle Arnal1 and
  • Jesús Avila1
SpringerPlus20154(Suppl 1):L16

https://doi.org/10.1186/2193-1801-4-S1-L16

Published: 12 June 2015

Keywords

Tau end binding proteins microtubule dynamics

Tau is a classical microtubule-associated protein known to regulate microtubule stability in neurons. In our study, we have addressed the putative crosstalk between tau and End binding proteins 1 and 3 (EB1/3), the core microtubule plus-end tracking proteins (+TIPs), in differentiating neuronal cells. We show that tau and EB proteins interact directly and that the cellular distribution and mobility of EB proteins depends on tau localization and expression levels. Moreover, our data reveal that tau is essential for the proper localization of EB1 at the medial-distal region of the axon shaft in developing neurons. In summary, we provide evidence for a new function of tau protein as a direct regulator of EB1/3 proteins. This further indicates that the interplay between classical MAPs and core +TIPs may be important for the fine-tuned regulation of microtubule dynamics and stability during neuronal differentiation.

Authors’ Affiliations

(1)
Centre for Biomedical Research of the Canary Islands (CIBICAN)
(2)
Institute for Biomedical Technologies (ITB)
(3)
University of La Laguna (ULL)

Copyright

© Sayas et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.