IL-6 in pg/mL in patients treated with epoprostenol or placebo. IL-6, IL-8, sICAM-1, CRP, and ADMA were measured ≤24 h, 25–48 h, 49–72 h, 73–96 h, and 97–120 h after trauma. These time ranges are denoted as 24, 48, 72, 96, and 120, respectively, in the figures. Values ≤24 hours were all sampled before the start of epoprostenol (E) or placebo (P) infusion. The numbers of patients at each time point are indicated in parentheses. Data are presented as Box plots. The horizontal line within the box indicates the median, the 25th to 75th percentiles are within the box, and the minimum and maximum values are shown with error bars. Dotted line = 43 pg/mL (reference value for IL-6 according to the manufacturer). *Statistically significant difference between the epoprostenol and the placebo group within 73–96 hours after trauma (p = 0.04, Mann-Whitney’s test).