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Table 4 Features differentiating Bartter and Gitelman syndromes

From: Mixed Bartter-Gitelman syndrome: an inbred family with a heterogeneous phenotype expression of a novel variant in the CLCNKB gene

Features Classic Bartter syndrome Gitelman syndrome
Age at onset Childhood (early) Childhood or later
Maternal hydramnios Rare Absent
Polyuria, polydipsia Present Rare
Dehydration Often present Absent
Tetany Rare Present
Growth retardation Present Absent
Urinary calcium Normal or high Low
Nephrocalcinosis Rare Absent
Serum magnesium Occasionally low Low
Urine prostaglandins (PGE2) High or normal Normal
  1. Modified from Urbanova et al. (Peters et al. 2002).