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Table 2 Risk of bias of the included studies judged by the review authors

From: A meta-analysis of efficacy and tolerability of buprenorphine for the relief of cancer pain

First author, publication year Random sequence generation Allocation concealment Blinding of participants Blinding of outcome assessment Duration
Aurilio 2009 Unclear High Unclear Unclear Unclear
Bohme 2003 Unclear Unclear Low Low Unclear
Bono 1997 Low Unclear Low Unclear Unclear
Brema 1996 Unclear Unclear Unclear Unclear Low
De Conno 1987 Unclear Unclear Unclear Unclear Unclear
Dini 1986 Unclear Unclear Low Unclear Unclear
Kjaer 1982 Unclear High Unclear Low Unclear
Likar 2007 Unclear Low High High Low
Noda 1989 Unclear Unclear Unclear Unclear High
Pace 2007 Low Unclear Unclear Unclear Unclear
Poulain 2008 Low Low Low Unclear Unclear
Sittl 2003 Unclear Unclear Unclear Unclear High
Sorge 2004 Low High High Unclear Unclear
Taguchi 1982 Unclear Unclear Low Unclear Unclear
Ventafridda 1983 Unclear Unclear Unclear Unclear Unclear
Wirz 2009 Low Unclear High High High
  1. Low: low risk of bias; high: high risk of bias; Unclear: Unclear risk of bias.