Table 1 Meta-analysis of the R72P polymorphism of the gene TP53 on breast cancer

Africa

Σ=189/181

1.13 (0.64-2.01)

1.40 (0.91-2.15)

1.16 (0.86-1.56)

Trifa et al., 2010

159/132

1.19 (0.65-2.19)

1.21 (0.75-1.96)

1.15 (0.83-1.61)

30/49

0.78 (0.18-3.40)

2.32 (0.93-5.78)

1.59 (0.78-3.27)

America

Σ=6,483/8,011

0.99 (0.87-1.12)

1.05 (0.88-1.26)

0.98 (0.92-1.02)

Damin et al., 2006

118/202

2.05 (0.83-5.09)

2.22 (1.40-3.53)

1.79 (1.25-2.55)

Aoki et al., 2009

72/90

1.78 (0.48-6.60)

2.47 (1.31-4.66)

1.85 (1.14-3.00)

Gaudet et al., 2008

578/390

1.11 (0.70-1.76)

0.78 (0.61-1.01)

0.88 (0.71-1.08)

Cox et al., 2007

1,477/2,224

0.83 (0.63-1.08)

0.92 (0.81-1.05)

0.92 (0.83-1.02)

Garcia-Closas et al. 2007

2,585/3,251

0.92 (0.75-1.12)

0.94 (0.84-1.04)

0.95 (0.87-1.03)

Sprague et al., 2007

1,653/1,854

1.16 (0.89-1.52)

1.00 (0.87-1.14)

1.02 (0.92-1.14)

Asia

Σ=2,570/2,833

1.21 (0.89-1.64)

1.08 (0.89-1.32)

*1.09 (1.01-1.17)

Lum et al., 2008

393/80

0.69 (0.37-1.30)

0.64 (0.39-1.06)

0.73 (0.51-1.03)

Gochhait et al., 2007

243/333

1.66 (1.12-2.46)

1.85 (1.28-2.67)

1.56 (1.23-1.92)

Huang et al., 2003

200/282

0.54 (0.32-0.92)

0.70 (0.48-1.02)

0.72 (0.55-0.93)

Ma et al. 2006

404/472

1.14 (0.82-1.59)

1.25 (0.95-1.66)

1.16 (0.96-1.40)

Rajkumar et al., 2008

250/500

1.27 (0.89-1. 80)

0.97 (0.69-1.37)

1.08 (0.87-1.34)

Li et al., 2002

28/50

1.38 (0.48-3.99)

2.54 (0.93-6.94)

1.68 (0.87-3.27)

Alawadi et al., 2011

288/188

6.12 (2.66-14.08)

1.08 (0.71-1.63)

1.31 (1.00-1.71)

Suresh et al., 2011

35/37

2.28 (0.59-8.91)

0.95 (0.35-2.57)

1.21 (0.62-2.34)

Kazemi et al., 2009

42/57

0.05 (0.003-0.89)

0.65 (0.23-1.84)

0.65 (0.37-1.15)

Singh et al., 2008

104/105

0.91 (0.40-2.06)

2.26 (1.21-3.85)

1.42 (0.96-2.11)

Khadang et al., 2007

221/205

1.60 (0.95-2.68)

1.04 (0.70-1.54)

1.17 (0.89-1.54)

Siddique et al., 2005

94/265

0.62 (0.34-1.12)

0.92 (0.57-1.49)

0.83 (0.59-1.16)

Noma et al., 2004

191/218

0.93 (0.54-1.60)

0.92 (0.62-1.35)

0.82 (0.61-1.10)

Katiyar et al., 2003

77/41

2.79 (0.93-8.39)

1.22 (0.51-2.95)

1.38 (0.80-2.36)

Europe

Σ=16,387/15,608

1.03 (0.95-11.25)

1.13 (1.00-1.27)

1.02 (0.99-1.06)

Sinilnikova et al., 2009

3,959/3,052

0.97 (0.80-1.16)

1.01 (0.92-1.11)

1.00 (0.93-1.08)

Cavallone et al., 2008

157/112

1.29 (0.52-3.21)

1.00 (0.62-1.63)

1.04 (0.71-1.53)

Baynes et al., 2007

2,023/2,197

1.04 (0.82-1.30)

1.05 (0.93-1.18)

1.04 (0.95-1.14)

Tommiska et al., 2005

1,551/733

1.02 (0.72-1.43)

0.93 (0.78-1.11)

0.96 (0.83-1.10)

Akkiprik et al. 2009

95/108

0.39 (0.14-1.12)

1.38 (0.78-2.42)

1.02 (0.65-1.91)

Kara et al., 2010

204/192

1.48 (0.73-3.00)

1.45 (0.98-2.15)

1.34 (0.99-1.81)

Bisof et al., 2010

95/107

0.48 (0.22-1.04)

0.48 (0.27-0.87)

0.58 (0.39-0.86)

Denisov et al., 2009

297/275

1.28 (0.73-2.23)

0.87 (0.62-1.20)

0.96 (0.75-1.25)

Henrıquez-Hernandez et al. 2009

135/295

1.60 (0.72-3.54)

0.90 (0.60-1.36)

1.03 (0.74-1.43)

Costa et al., 2008

248/646

0.81 (0.49-1.32)

0.86 (0.64-1.16)

0.87 (0.69-1.10)

Buyru et al., 2007

115/63

1.44 (0.58-3.57)

1.77 (0.96-3.29)

1.52 (0.96-2.43)

Johnson et al., 2007

472/2,462

1.17 (0.79-1.74)

0.98 (0.80-1.19)

1.01 (0.87-1.19)

Schmidt et al. 2007

5,191/3,834

1.01 (0.86-1.18)

1.05 (0.96-1.14)

1.03 (0.96-1.10)

Kalemi et al., 2005

42/51

2.52 (0.69-9.26)

6.35 (2.54-15.84)

3.29 (1.73-6.25)

Ohayon et al., 2005

132/167

4.86 (1.52-15.53)

4.29 (4.68-6.96)

3.10 (2.10-4.56)

Menzel et al., 2004

475/302

1.64 (0.97-2.76)

1.25 (0.94-1.67)

1.27 (1.01-1.60)

Buyru et al., 2003

115/76

1.61 (0.69-3.73)

3.23 (1.7-6.00)

2.09 (1.36-3.22)

Suspitsin et al., 2003

529/393

0.86 (0.52-1.41)

1.04 (0.80-1.35)

1.00 (0.81-1.23)

Wang-Gohrke et al., 2002

552/543

0.82 (0.53-1.26)

0.85 (0.67-1.07)

0.87 (0.72-1.05)

Overall

25,629/26,633

1.09 (0.98-1.22)

*1.11 (1.02-1.21)

1.02 (1.00-1.05)

Heterogeneity

χ² = 80.19

χ² = 146.02

χ² = 6.54

P = 0.0002

P<0.0001

P = 0.088