Skip to main content

Table 1 Meta-analysis of the R72P polymorphism of the gene TP53 on breast cancer

From: Association of the TP53 codon 72 polymorphism and breast cancer risk: a meta-analysis

Studies/continent No. of case/control RR + RP vs. PP RR vs. RP + PP R vs. P
   OR (95% CI) OR (95% CI) OR (95% CI)
Africa Σ=189/181 1.13 (0.64-2.01) 1.40 (0.91-2.15) 1.16 (0.86-1.56)
Trifa et al., 2010 159/132 1.19 (0.65-2.19) 1.21 (0.75-1.96) 1.15 (0.83-1.61)
Mabrouk et al., 2003 30/49 0.78 (0.18-3.40) 2.32 (0.93-5.78) 1.59 (0.78-3.27)
America Σ=6,483/8,011 0.99 (0.87-1.12) 1.05 (0.88-1.26) 0.98 (0.92-1.02)
Damin et al., 2006 118/202 2.05 (0.83-5.09) 2.22 (1.40-3.53) 1.79 (1.25-2.55)
Aoki et al., 2009 72/90 1.78 (0.48-6.60) 2.47 (1.31-4.66) 1.85 (1.14-3.00)
Gaudet et al., 2008 578/390 1.11 (0.70-1.76) 0.78 (0.61-1.01) 0.88 (0.71-1.08)
Cox et al., 2007 1,477/2,224 0.83 (0.63-1.08) 0.92 (0.81-1.05) 0.92 (0.83-1.02)
Garcia-Closas et al. 2007 2,585/3,251 0.92 (0.75-1.12) 0.94 (0.84-1.04) 0.95 (0.87-1.03)
Sprague et al., 2007 1,653/1,854 1.16 (0.89-1.52) 1.00 (0.87-1.14) 1.02 (0.92-1.14)
Asia Σ=2,570/2,833 1.21 (0.89-1.64) 1.08 (0.89-1.32) *1.09 (1.01-1.17)
Lum et al., 2008 393/80 0.69 (0.37-1.30) 0.64 (0.39-1.06) 0.73 (0.51-1.03)
Gochhait et al., 2007 243/333 1.66 (1.12-2.46) 1.85 (1.28-2.67) 1.56 (1.23-1.92)
Huang et al., 2003 200/282 0.54 (0.32-0.92) 0.70 (0.48-1.02) 0.72 (0.55-0.93)
Ma et al. 2006 404/472 1.14 (0.82-1.59) 1.25 (0.95-1.66) 1.16 (0.96-1.40)
Rajkumar et al., 2008 250/500 1.27 (0.89-1. 80) 0.97 (0.69-1.37) 1.08 (0.87-1.34)
Li et al., 2002 28/50 1.38 (0.48-3.99) 2.54 (0.93-6.94) 1.68 (0.87-3.27)
Alawadi et al., 2011 288/188 6.12 (2.66-14.08) 1.08 (0.71-1.63) 1.31 (1.00-1.71)
Suresh et al., 2011 35/37 2.28 (0.59-8.91) 0.95 (0.35-2.57) 1.21 (0.62-2.34)
Kazemi et al., 2009 42/57 0.05 (0.003-0.89) 0.65 (0.23-1.84) 0.65 (0.37-1.15)
Singh et al., 2008 104/105 0.91 (0.40-2.06) 2.26 (1.21-3.85) 1.42 (0.96-2.11)
Khadang et al., 2007 221/205 1.60 (0.95-2.68) 1.04 (0.70-1.54) 1.17 (0.89-1.54)
Siddique et al., 2005 94/265 0.62 (0.34-1.12) 0.92 (0.57-1.49) 0.83 (0.59-1.16)
Noma et al., 2004 191/218 0.93 (0.54-1.60) 0.92 (0.62-1.35) 0.82 (0.61-1.10)
Katiyar et al., 2003 77/41 2.79 (0.93-8.39) 1.22 (0.51-2.95) 1.38 (0.80-2.36)
Europe Σ=16,387/15,608 1.03 (0.95-11.25) 1.13 (1.00-1.27) 1.02 (0.99-1.06)
Sinilnikova et al., 2009 3,959/3,052 0.97 (0.80-1.16) 1.01 (0.92-1.11) 1.00 (0.93-1.08)
Cavallone et al., 2008 157/112 1.29 (0.52-3.21) 1.00 (0.62-1.63) 1.04 (0.71-1.53)
Baynes et al., 2007 2,023/2,197 1.04 (0.82-1.30) 1.05 (0.93-1.18) 1.04 (0.95-1.14)
Tommiska et al., 2005 1,551/733 1.02 (0.72-1.43) 0.93 (0.78-1.11) 0.96 (0.83-1.10)
Akkiprik et al. 2009 95/108 0.39 (0.14-1.12) 1.38 (0.78-2.42) 1.02 (0.65-1.91)
Kara et al., 2010 204/192 1.48 (0.73-3.00) 1.45 (0.98-2.15) 1.34 (0.99-1.81)
Bisof et al., 2010 95/107 0.48 (0.22-1.04) 0.48 (0.27-0.87) 0.58 (0.39-0.86)
Denisov et al., 2009 297/275 1.28 (0.73-2.23) 0.87 (0.62-1.20) 0.96 (0.75-1.25)
Henrıquez-Hernandez et al. 2009 135/295 1.60 (0.72-3.54) 0.90 (0.60-1.36) 1.03 (0.74-1.43)
Costa et al., 2008 248/646 0.81 (0.49-1.32) 0.86 (0.64-1.16) 0.87 (0.69-1.10)
Buyru et al., 2007 115/63 1.44 (0.58-3.57) 1.77 (0.96-3.29) 1.52 (0.96-2.43)
Johnson et al., 2007 472/2,462 1.17 (0.79-1.74) 0.98 (0.80-1.19) 1.01 (0.87-1.19)
Schmidt et al. 2007 5,191/3,834 1.01 (0.86-1.18) 1.05 (0.96-1.14) 1.03 (0.96-1.10)
Kalemi et al., 2005 42/51 2.52 (0.69-9.26) 6.35 (2.54-15.84) 3.29 (1.73-6.25)
Ohayon et al., 2005 132/167 4.86 (1.52-15.53) 4.29 (4.68-6.96) 3.10 (2.10-4.56)
Menzel et al., 2004 475/302 1.64 (0.97-2.76) 1.25 (0.94-1.67) 1.27 (1.01-1.60)
Buyru et al., 2003 115/76 1.61 (0.69-3.73) 3.23 (1.7-6.00) 2.09 (1.36-3.22)
Suspitsin et al., 2003 529/393 0.86 (0.52-1.41) 1.04 (0.80-1.35) 1.00 (0.81-1.23)
Wang-Gohrke et al., 2002 552/543 0.82 (0.53-1.26) 0.85 (0.67-1.07) 0.87 (0.72-1.05)
Overall 25,629/26,633 1.09 (0.98-1.22) *1.11 (1.02-1.21) 1.02 (1.00-1.05)
Heterogeneity χ2 = 80.19 χ2 = 146.02 χ2 = 6.54
  P = 0.0002 P<0.0001 P = 0.088