Table 1 Sensitivity of HEK cells to troxacitabine, Ara-C and gemcitabine in comparison to PMEA

Troxacitabine

4 h

11.0 ± 2.6

29.0 ± 4.0**

2.6

14.2 ± 3.0⁺

1.3

72 h

3.3 ± 0.2

5.0 ± 0.8

1.5

2.0 ± 0.1⁺

0.61

Ratio IC50

4/72 h

3.3

5.9

7.1

Ara-C

4 h

8.3 ± 0.6

23.3 ± 4.4*

2.8

17.7 ± 1.5**

2.1

72 h

2.5 ± 1.5

5.4 ± 1.6

2.2

4.0 ± 1.5

1.6

Ratio IC50

4/72 h

3.3

4.3

4.4

Gemcitabine

4 h

0.43 ± 0.08

0.60 ± 0.12

1.4

0.50 ± 0.06

1.2

72 h

0.046 ± 0.006

0.061 ± 0.008

1.3

0.07 ± 0.01

1.5

Ratio IC50

4/72 h

9.3

10.0

7.1

PMEA

4 h

600 ± 40

2500 ± 100**

4.2

2567 ± 550**

4.3