Figure 7From: Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabineAccumulation and retention of dFdCTP in the HEK, HEK/MRP4 and HEK/MRP5i cell lines. T = 4: 4 hours exposure to 25 μM dFdC, T = 4 + 2: 4 hours exposure to dFdC followed by 2 hours drug-free medium. Values represent dFdCTP/ATP ratio ± SEM of 3 separate experiments. The accumulation of dFdCTP was significantly higher in HEK/MRP5i cells compared to wild type HEK cells (+, p < 0.05) (unpaired t test). Accumulation was measured in the absence of indomethacin or probenecid.Back to article page