Figure 1

A punch biopsy of the tongue base showed a diffuse dense infiltration of the lymphoid cells (x 400). (A) Immunohistochemical staining of tumor cells. (B) The tumor cells showed a diffuse cytoplasmic immunopositivity for CD3 (x400), but tumor cells were immunonegative for CD20, CD30, and CD56. The immunophenotype of tumor cells were mixed pattern for CD4 and CD8. (C) The tumor cells expressed cytotoxic granule associated proteins TIA-1 and granzyme B. (D) The proliferation index by Ki-67 immunostain expressed with a high level (about 80%).