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Table 4 Odds of TNBC compared to non-TNBC according to family history of breast and/or ovarian cancer, stratified by participant’s age at diagnosis

From: Family history of breast and ovarian cancer and triple negative subtype in hispanic/latina women

Family history Age of diagnosis < 50 y Age of diagnosis ≥ 50 y
  TNBC OR (95% CI)* TNBC OR (95% CI)*
  n/total (%)   n/total (%)  
Breast cancer in first-degree relatives     
  No 66/361 (18.3) 1.00 50/418 (12.0) 1.00
  Yes 21/58 (36.2) 2.61 (1.43–4.77) 11/77 (14.3) 1.38 (0.68–2.83)
  P-interaction = 0.14**
Breast cancer in first- or second-degree relatives     
  No 47/297 (15.8) 1.00 45/381 (11.8) 1.00
  Yes 40/122 (32.8) 2.67 (1.63–4.37) 16/114 (14.0) 1.37 (0.73–2.56)
  P-interaction = 0.07**
Breast or ovarian cancer in first-degree relatives     
  No 66/357 (18.5) 1.00 46/402 (11.4) 1.00
  Yes 21/62 (33.9) 2.31 (1.28–4.18) 15/93 (16.1) 1.61 (0.85–3.06)
  P-interaction = 0.36**
  1. *Adjusted for country of residence (U.S. or Mexico).
  2. **Interaction between age at diagnosis and family history on TNBC subtype.