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Table 4 Odds of TNBC compared to non-TNBC according to family history of breast and/or ovarian cancer, stratified by participant’s age at diagnosis

From: Family history of breast and ovarian cancer and triple negative subtype in hispanic/latina women

Family history

Age of diagnosis < 50 y

Age of diagnosis ≥ 50 y

 

TNBC

OR (95% CI)*

TNBC

OR (95% CI)*

 

n/total (%)

 

n/total (%)

 

Breast cancer in first-degree relatives

    

  No

66/361 (18.3)

1.00

50/418 (12.0)

1.00

  Yes

21/58 (36.2)

2.61 (1.43–4.77)

11/77 (14.3)

1.38 (0.68–2.83)

 

P-interaction = 0.14**

Breast cancer in first- or second-degree relatives

    

  No

47/297 (15.8)

1.00

45/381 (11.8)

1.00

  Yes

40/122 (32.8)

2.67 (1.63–4.37)

16/114 (14.0)

1.37 (0.73–2.56)

 

P-interaction = 0.07**

Breast or ovarian cancer in first-degree relatives

    

  No

66/357 (18.5)

1.00

46/402 (11.4)

1.00

  Yes

21/62 (33.9)

2.31 (1.28–4.18)

15/93 (16.1)

1.61 (0.85–3.06)

 

P-interaction = 0.36**

  1. *Adjusted for country of residence (U.S. or Mexico).
  2. **Interaction between age at diagnosis and family history on TNBC subtype.