Table 5 Prognostic factors of overall survival of hepatocellular carcinoma

Age (> 65 years vs. 0–65 years)

1.474 (0.904–2.404)

0.120

Sex (female vs. male)

1.086 (0.629–1.876)

0.767

HBV (positive vs. negative)

0.809 (0.443–1.478)

0.491

HCV (positive vs. negative)

1.661 (1.014–2.722)

0.044

2.093 (1.260–3.479)

0.004

Child-Pugh (B vs. A)

1.602 (0.860–2.983)

0.138

AFP (>20 ng/ml vs. 0–20 ng/ml)

1.274 (0.797–2.036)

0.312

Tumor size (>5 cm vs. 0–5 cm)

2.350 (1.462–3.775)

<0.001

1.250 (0.715–2.187)

0.434

Histologic grade (por vs. well/mod)

2.868 (1.777–4.628)

<0.001

1.811 (1.045–3.136)

0.034

Vascular invasion (present vs. absent)

3.724 (2.072–6.691)

<0.001

1.928 (0.983–3.780)

0.056

Intrahepatic metastasis (present vs. absent)

4.215 (2.628–6.760)

<0.001

3.030 (1.737–5.286)

<0.001

Background liver (LC vs. non-LC)

1.303 (0.811–2.094)

0.274

SALL4 (positive vs. negative)

1.155 (0.591–2.255)

0.674

Cytokeratin 19 (positive vs. negative)

2.722 (1.607-4.612)

<0.001

1.738 (0.973-3.105)

0.062

EpCAM (positive vs. negagtive)

1.615 (0.884–2.951)

0.119