|
Prognostic factor
|
n
|
# events
|
HR
|
95% CI
|
p-value
|
|---|
|
Age (years)
|
192
|
60
|
0.97
|
0.95-0.99
|
0.01
|
|
Tumour size (mm)
| | | | | |
|
≤20
|
108
|
24
|
1.0
| | |
|
>20
|
81
|
36
|
2.7
|
1.6-4.5
|
<0.001
|
|
Nodal status (p <0.001)a
| | | | | |
|
0
|
107
|
27
|
1.0
| | |
|
1-3+
|
36
|
10
|
1.1
|
0.55-2.4
|
0.73
|
|
>3+
|
38
|
21
|
3.5
|
2.0-6.2
|
<0.001
|
|
Histological grade (p =0.01)a
| | | | | |
|
1
|
28
|
5
|
0.54
|
0.21-1.4
|
0.19
|
|
2
|
133
|
43
|
1.0
| | |
|
3
|
14
|
6
|
2.8
|
1.2-6.7
|
0.02
|
|
Tubule formation
| | | | | |
|
2
|
13
|
3
|
1.0
| | |
|
3
|
162
|
51
|
1.3
|
0.39-4.0
|
0.70
|
|
Pleomorphism (p =0.04)a
| | | | | |
|
1
|
20
|
5
|
0.88
|
0.34-2.3
|
0.80
|
|
2
|
112
|
31
|
1.0
| | |
|
3
|
43
|
18
|
1.9
|
1.0-3.3
|
0.03
|
|
Mitotic score (p <0.001)a
| | | | | |
|
1
|
155
|
45
|
1.0
| | |
|
2
|
10
|
4
|
2.0
|
0.71-5.6
|
0.19
|
|
3
|
10
|
5
|
4.2
|
1.7-11
|
0.003
|
|
ER
| | | | | |
|
+
|
169
|
50
|
1.0
| | |
|
-
|
23
|
10
|
1.6
|
0.83-3.3
|
0.15
|
|
PgR
| | | | | |
|
+
|
97
|
27
|
1.0
| | |
|
-
|
95
|
33
|
1.4
|
0.85-2.4
|
0.18
|
|
Ki67 (p = 0.01)a
| | | | | |
|
0-10%
|
115
|
30
|
1.0
| | |
|
11-30%
|
62
|
22
|
1.4
|
0.84-2.5
|
0.19
|
|
>30%
|
15
|
8
|
2.6
|
1.2-5.8
|
0.01
|
|
KiGE
| | | | | |
|
Low
|
136
|
35
|
1.0
| | |
|
High
|
39
|
19
|
2.8
|
1.6-5.0
|
<0.001
|
- aLog-rank test for trend.
