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Table 4 Univariable analysis of breast cancer mortality in invasive lobular carcinoma

From: Invasive lobular carcinoma of the breast: long-term prognostic value of Ki67 and histological grade, alone and in combination with estrogen receptor

Prognostic factor n # events HR 95% CI p-value
Age (years) 192 60 0.97 0.95-0.99 0.01
Tumour size (mm)      
  ≤20 108 24 1.0   
  >20 81 36 2.7 1.6-4.5 <0.001
Nodal status (p <0.001)a      
  0 107 27 1.0   
  1-3+ 36 10 1.1 0.55-2.4 0.73
  >3+ 38 21 3.5 2.0-6.2 <0.001
Histological grade (p =0.01)a      
  1 28 5 0.54 0.21-1.4 0.19
  2 133 43 1.0   
  3 14 6 2.8 1.2-6.7 0.02
Tubule formation      
  2 13 3 1.0   
  3 162 51 1.3 0.39-4.0 0.70
Pleomorphism (p =0.04)a      
  1 20 5 0.88 0.34-2.3 0.80
  2 112 31 1.0   
  3 43 18 1.9 1.0-3.3 0.03
Mitotic score (p <0.001)a      
  1 155 45 1.0   
  2 10 4 2.0 0.71-5.6 0.19
  3 10 5 4.2 1.7-11 0.003
ER      
  + 169 50 1.0   
  - 23 10 1.6 0.83-3.3 0.15
PgR      
  + 97 27 1.0   
  - 95 33 1.4 0.85-2.4 0.18
Ki67 (p = 0.01)a      
  0-10% 115 30 1.0   
  11-30% 62 22 1.4 0.84-2.5 0.19
  >30% 15 8 2.6 1.2-5.8 0.01
KiGE      
  Low 136 35 1.0   
  High 39 19 2.8 1.6-5.0 <0.001
  1. aLog-rank test for trend.