Invasive lobular carcinoma of the breast: long-term prognostic value of Ki67 and histological grade, alone and in combination with estrogen receptor

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Table 4 Univariable analysis of breast cancer mortality in invasive lobular carcinoma

Prognostic factor	n	# events	HR	95% CI	p-value
Age (years)	192	60	0.97	0.95-0.99	0.01
Tumour size (mm)
≤20	108	24	1.0
>20	81	36	2.7	1.6-4.5	<0.001
Nodal status (p <0.001)^a
0	107	27	1.0
1-3+	36	10	1.1	0.55-2.4	0.73
>3+	38	21	3.5	2.0-6.2	<0.001
Histological grade (p =0.01)^a
1	28	5	0.54	0.21-1.4	0.19
2	133	43	1.0
3	14	6	2.8	1.2-6.7	0.02
Tubule formation
2	13	3	1.0
3	162	51	1.3	0.39-4.0	0.70
Pleomorphism (p =0.04)^a
1	20	5	0.88	0.34-2.3	0.80
2	112	31	1.0
3	43	18	1.9	1.0-3.3	0.03
Mitotic score (p <0.001)^a
1	155	45	1.0
2	10	4	2.0	0.71-5.6	0.19
3	10	5	4.2	1.7-11	0.003
ER
+	169	50	1.0
-	23	10	1.6	0.83-3.3	0.15
PgR
+	97	27	1.0
-	95	33	1.4	0.85-2.4	0.18
Ki67 (p = 0.01)^a
0-10%	115	30	1.0
11-30%	62	22	1.4	0.84-2.5	0.19
>30%	15	8	2.6	1.2-5.8	0.01
KiGE
Low	136	35	1.0
High	39	19	2.8	1.6-5.0	<0.001