Ventilatory response to exercise in adolescents with cystic fibrosis and mild-to-moderate airway obstruction

Bongers, Bart C.; Werkman, Maarten S.; Takken, Tim; Hulzebos, Erik H. J.

doi:10.1186/2193-1801-3-696

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Table 2 Exercise performance in the healthy adolescents and adolescents with CF

From: Ventilatory response to exercise in adolescents with cystic fibrosis and mild-to-moderate airway obstruction

	Healthy (n = 22)	CF (n = 22)	P-value
Maximal values
HR_peak (beats · min⁻¹)	192 ± 7	186 ± 8	0.02*
RER_peak	1.15 ± 0.08	1.19 ± 0.09	0.16
WR_peak (W)	222 ± 62	164 ± 32	<0.01**
WR_peak/kg (W · kg⁻¹)	4.2 ± 0.6	3.3 ± 0.5	<0.001***
VO_2peak (mL · min⁻¹)	2638 ± 685	2126 ± 516	0.01*
VO_2peak/kg (mL · kg⁻¹ · min⁻¹)	49.1 ± 7.2	42.4 ± 8.7	<0.01**
VO_2peak/BSA (mL · m² · min⁻¹)	1667 ± 259	1378 ± 274	<0.01**
VCO_2peak (mL · min⁻¹)	2963 ± 871	2409 ± 540	0.03*
VCO_2peak/kg (mL · kg⁻¹ · min⁻¹)	54.9 ± 8.9	48.1 ± 9.7	0.02*
VE @ VO_2peak (L · min⁻¹)	89.5 ± 27.2	75.8 ± 18.8	0.08
VE/kg @ VO_2peak (L · kg⁻¹ · min⁻¹)	1.7 ± 0.3	1.5 ± 0.3	0.04*
Absolute tidal volume @ VO_2peak (mL)	1736 ± 339	1616 ± 373	0.32
Relative tidal volume @ VO_2peak (mL · kg⁻¹)	32.7 ± 4.8	32.2 ± 6.4	0.98
Breathing frequency @ VO_2peak (breaths · min⁻¹)	51 ± 9	48 ± 9	0.25
Estimated VD/VT ratio @ VO_2peak (%)	17 ± 2	21 ± 4	<0.001***
P_ETCO₂ @ VO_2peak (mmHg)	36.3 ± 3.2	38.2 ± 3.7	0.10
VE/WR ratio @ VO_2peak (mL · min⁻¹ · W⁻¹)	399 ± 57	476 ± 71	<0.001***
Submaximal values
Absolute ventilatory threshold (mL · min⁻¹)	1439 ± 381	1216 ± 253	0.07
Relative ventilatory threshold (mL · kg⁻¹ · min⁻¹)	27.1 ± 6.1	24.4 ± 5.1	0.13
Ventilatory threshold (%VO_2peak)	55 ± 9	58 ± 9	0.32
P_ETCO₂ @ rest (mmHg)	31.8 ± 2.4	33.5 ± 3.2	0.03*
P_ETCO₂ @ the ventilatory threshold (mmHg)	39.3 ± 3.6	40.0 ± 2.6	0.50
VE/VO₂-slope up to the ventilatory threshold	20.5 ± 3.2	23.7 ± 5.1	0.02*
VE/VCO₂-slope up to the respiratory compensation point	26.6 ± 2.8	27.1 ± 2.9	0.60

Values are presented as mean ± SD.
Abbreviations: BSA body surface area, CF cystic fibrosis, HR_peak peak heart rate, NS not statistically significant, P_ETCO₂ partial end-tidal carbon dioxide tension, RER_peak peak respiratory exchange ratio, VCO_2peak peak carbon dioxide output, VCO_2peak/kg peak carbon dioxide output normalized for body mass, VD/VT ratio physiological dead space ventilation, VE minute ventilation, VE/kg minute ventilation normalized for body mass, VE/VCO₂-slope slope of the relationship between minute ventilation and carbon dioxide output, VE/VO₂-slope slope of the relationship between minute ventilation and oxygen uptake, VE/WR minute ventilation to work rate ratio, VO_2peak peak oxygen uptake, VO_2peak/kg peak oxygen uptake normalized for body mass, WR_peak peak work rate, WR_peak/kg peak work rate normalized for body mass.
*P < 0.05; **P < 0.01; ***P < 0.001.

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