Ventilatory response to exercise in adolescents with cystic fibrosis and mild-to-moderate airway obstruction

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Table 1 Participant characteristics

	Healthy (n = 22)	CF (n = 22)	P-value
Sex (boy/girl)	12/10	12/10	NA
Age (years)	14.3 ± 1.4	14.3 ± 1.3	0.99
CF mutation class (I/II/IV/unknown)^a	NA	9/27/1/6	NA
PA colonization (never/free of infection/intermittent/chronic)^b	NA	6/1/6/9	NA
Body height (m)	1.67 ± 0.10	1.65 ± 0.09	0.61
Body height for age SDS^c	0.17 ± 0.86	−0.18 ± 0.99	0.24
Body mass (kg)	53.9 ± 12.2	50.2 ± 7.2	0.31
Body mass for age SDS^c	0.02 ± 0.83	−0.37 ± 0.64	0.13
BMI (kg · m⁻²)	19.1 ± 2.6	18.5 ± 2.0	0.51
BMI for age SDS^c	−0.09 ± 0.80	−0.34 ± 0.85	0.37
BSA (m²)	1.57 ± 0.22	1.54 ± 0.14	0.72
FEV₁ (L)	NA	2.52 ± 0.67	NA
FEV₁ (%pred)^d	NA	78.6 ± 17.3	NA
RV/TLC (%)	NA	33.5 ± 9.3	NA
VO_2peak/kg (mL · kg⁻¹ · min⁻¹)	49.1 ± 7.2	42.4 ± 8.7	<0.01**

Values are presented as mean ± SD.
Abbreviations: BMI body mass index, BSA body surface area, CF cystic fibrosis, CFTR cystic fibrosis transmembrane conductance regulator, FEV₁ forced expiratory volume in one second, NA not applicable, NS not statistically significant, RV/TLC residual volume to total lung capacity ratio, SDS standard deviation score.
**P < 0.01.
^aBased on the classification of CFTR alleles used by Green et al. (2010).
^bBased on the criteria of Lee et al. (2003).
^cReference values of Fredriks et al. (2000).
^dReference values of Zapletal et al. (1987).