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Table 3 Sequence based prediction of the effect of single amino acid substitutions on ERG11 of Candida albicans

From: Structural basis for heterogeneous phenotype of ERG11 dependent Azole resistance in C.albicans clinical isolates

Sl.no Mutant Classifiers
Polyphen Provean I-MUTANT MutPred
Score Prediction Score Prediction Effect DDG value (Kcal/mol) Probability of deleterious mutation
1 ERG11_D116E 0.003 (sensitivity: 0.98; specificity: 0.44) Benign 0.695 Neutral Neutral -0.47 0.672
  ERG11_Y118A 1.000 (sensitivity: 0.00; specificity: 1.00) Probably Damaging -9.487 Deleterious Large Decrease in stability -1.83 0.764
2 ERG11_P230L 0.997 (sensitivity: 0.41; specificity: 0.98) Probably Damaging -8.773 Deleterious Large Decrease in stability -0.97 0.849
3 ERG_F380L 0.831 (sensitivity: 0.95; specificity: 0.82) Probably Damaging -3.075 Deleterious Large Decrease in stability -1.28 0.583
4 ERG11_K342R 0.005 (sensitivity: 0.97; specificity: 0.74) Benign -0.443 Neutral Neutral -0.17 0.389