Cigarette smoking and breast cancer risk in relation to joint estrogen and progesterone receptor status: a case-control study in Japan

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Table 5 Odds ratio (OR) according to passive smoking by hormone receptor status

	Controls	ER+/PgR+ (n = 445)					ER+/PgR- (n = 97)					ER-/PgR+ (n = 16)					ER-/PgR- (n = 215)					P _{heterogeneity}
	Controls	Cases	OR	95% CI			Cases	OR	95% CI			Cases	OR	95% CI			Cases	OR	95% CI			ER+/PgR+ vs ER-/PgR-
Passive smoking (husband’s smoking)
Never smoker	744	150	1 (Reference)				36	1 (Reference)				7	1 (Reference)				73	1 (Reference)
Current	826	176	1.13	0.88	-	1.47	36	0.99	0.60	-	1.61	9	1.72	0.56	-	5.27	94	1.17	0.83	-	1.63
Past	487	119	1.11	0.84	-	1.47	25	0.96	0.56	-	1.65	0	-	-	-	-	48	0.93	0.63	-	1.38
Ever	1313	295	1.13	0.90	-	1.42	61	0.98	0.63	-	1.51	9	1.01	0.34	-	2.98	142	1.07	0.79	-	1.46	0.78
Analyzed for never-smoking married women.

Adjusted by age (continuous), BMI (< 18.5, 18.5 ≤ < 25.0, 25.0 ≤ < 30.0, 30.0 ≤), occupation (professional or clerical work, industrial work or fishery, agriculture or forestry, other), physical activity (almost no, more than one hour per week), menopausal status (premenopausal, postmenopausal), age at menarche (≤ 12, 13, 14, 15 ≤), age at menopause (< 48, 48 ≤ < 51, 51 ≤ < 54, 54 ≤), age at first birth (≤ 24, 25 ≤ ≤ 29, 30 ≤ ≤ 50), family history of breast cancer in mother or sister (yes, no), parity number (0, 1, 2, 3 ≤), use of exogenous female hormone or oral contraceptives (yes, no), referrel status (from screening, other), year of recruitment (continuous), area of residence (Southern Miyagi prefecture, other area) and alcohol drinking (never, current or past).