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Table 2 Odds ratio (OR) according to smoking status by hormone receptor status

From: Cigarette smoking and breast cancer risk in relation to joint estrogen and progesterone receptor status: a case-control study in Japan

 

ER+/PgR+ (n = 672)

ER+/PgR- (n = 158)

ER-/PgR+ (n = 22)

ER-/PgR- (n = 308)

P heterogeneity

Controls

Cases

OR

95% CI

p

Cases

OR

95% CI

p

Cases

OR

95% CI

p

Cases

OR

95% CI

p

ER+/PgR+ vs ER-/PgR-

History of smoking

 Never smoker

2629

555

1 (Reference)

 

129

1 (Reference)

 

17

1 (Reference)

 

256

1 (Reference)

  

 Current

408

84

0.86

0.65

-

1.14

 

18

0.99

0.58

-

1.69

 

3

1.06

0.28

-

4.12

 

38

0.84

0.57

-

1.23

  

 Past

123

33

0.92

0.60

-

1.41

 

11

1.80

0.92

-

3.53

 

2

2.53

0.49

-

12.96

 

14

1.02

0.57

-

1.83

  

 Ever

531

117

0.88

0.68

-

1.12

 

29

1.20

0.76

-

1.88

 

5

1.40

0.45

-

4.32

 

52

0.88

0.63

-

1.24

 

0.96

Age at the start of smoking (years)

 Never smoker

2629

555

1 (Reference)

 

129

1 (Reference)

 

17

1 (Reference)

 

256

1 (Reference)

  

 26 ≤

166

28

0.85

0.55

-

1.31

 

10

1.22

0.61

-

2.43

 

0

-

-

-

-

 

13

0.73

0.40

-

1.33

  

 20 ≤ ≤ 25

253

63

0.90

0.65

-

1.24

 

12

1.01

0.52

-

1.94

 

4

2.12

0.60

-

7.51

 

25

0.89

0.56

-

1.41

  

 ≤ 19

60

16

0.91

0.49

-

1.67

 

2

0.83

0.19

-

3.59

 

0

-

-

-

-

 

10

1.55

0.76

-

3.20

  

p for trend

      

0.42

     

0.94

     

0.58

     

0.95

0.57

Smoking started before first birth

 Never smoker

2629

555

1 (Reference)

 

129

1 (Reference)

 

17

1 (Reference)

 

256

1 (Reference)

  

 No

179

30

0.86

0.56

-

1.31

 

9

0.99

0.48

-

2.03

 

-

-

-

-

-

 

14

0.70

0.40

-

1.26

  

 Yes

193

53

0.95

0.67

-

1.35

 

12

1.36

0.70

-

2.65

 

4

2.30

0.63

-

8.38

 

23

0.97

0.60

-

1.59

  

 Uncertain

27

6

1.02

0.40

-

2.62

 

1

0.96

0.13

-

7.39

 

-

-

-

-

-

 

3

0.97

0.28

-

3.31

  

Number of cigarettes per day

 Never smoker

2629

555

1 (Reference)

 

129

1 (Reference)

 

17

1 (Reference)

 

256

1 (Reference)

  

 0 < ≤ 10

255

58

0.87

0.62

-

1.20

 

13

1.12

0.60

-

2.09

 

3

1.90

0.47

-

7.71

 

22

0.77

0.48

-

1.25

  

 11 ≤

229

51

0.92

0.65

-

1.30

 

11

1.01

0.52

-

1.97

 

1

0.61

0.07

-

5.15

 

25

0.99

0.63

-

1.56

  

p for trend

      

0.47

     

0.87

     

0.94

     

0.68

0.92

Duration of smoking (years)

 Never smoker

2629

555

1 (Reference)

 

129

1 (Reference)

 

17

1 (Reference)

 

256

1 (Reference)

  

 0 < ≤ 21

242

48

0.70

0.49

-

1.00

 

11

1.02

0.52

-

2.02

 

2

1.07

0.21

-

5.50

 

21

0.78

0.47

-

1.29

  

 21 <

226

52

1.00

0.71

-

1.40

 

12

1.09

0.58

-

2.06

 

2

1.52

0.31

-

7.41

 

25

1.01

0.64

-

1.59

  

p for trend

      

0.49

     

0.80

     

0.63

     

0.77

0.85

Pack-years

 Never smoker

2629

555

1 (Reference)

 

129

1 (Reference)

 

17

1 (Reference)

 

256

1 (Reference)

  

 0 < ≤ 13

238

48

0.71

0.50

-

1.02

 

12

1.18

0.61

-

2.27

 

3

1.67

0.41

-

6.86

 

17

0.63

0.37

-

1.09

  

 13 <

225

52

1.01

0.72

-

1.42

 

10

0.89

0.45

-

1.76

 

1

0.75

0.09

-

6.24

 

28

1.13

0.73

-

1.75

  

p for trend

      

0.54

     

0.88

     

0.94

     

0.97

0.71

  1. All models were adjusted by age (continuous), BMI (< 18.5, 18.5 ≤ < 25.0, 25.0 ≤ < 30.0, 30.0 ≤), occupation (professional or clerical work, industrial work or fishery, agriculture or forestry, other), physical activity (almost no, more than one hour per week), menopausal status (premenopausal, postmenopausal), age at menarche (≤ 12, 13, 14, 15 ≤), age at menopause (< 48, 48 ≤ < 51, 51 ≤ < 54, 54 ≤), age at first birth (≤ 24, 25 ≤ ≤ 29, 30 ≤ ≤ 50), family history of breast cancer in mother or sister (yes, no), parity number (0, 1, 2, 3 ≤), use of exogenous female hormone or oral contraceptives (yes, no), referrel status (from screening, other), year of recruitment (continuous), area of residence (Southern Miyagi prefecture, other area) and alcohol drinking (never, current or past).
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